TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: Sodium oxybate is efficacious across multiple narcolepsy symptom domains, including excessive daytime sleepiness; currently approved formulations require twice-nightly dosing. The efficacy and safety of FT218, an investigational, extended-release formulation once-nightly sodium (ON-SXB), were analyzed in adults with the pivotal REST-...

Open AccessJournal of UrologyAdult Urology1 May 2021Efficacy Enzalutamide plus Androgen Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer by Pattern Spread: ARCHES Post Hoc AnalysesThis article is commented on the following:Editorial Comment Andrew J. Armstrong, Neal D. Shore, Russell Z. Szmulewitz, Daniel P. Petrylak, Jeffrey Holzbeierlein, Arnauld Villers, Arun Azad, Antonio...

Abstract Introduction In the REST-ON trial (NCT02720744), once-nightly sodium oxybate (ON-SXB; FT218) was associated with significant improvement vs placebo for mean sleep latency on Maintenance of Wakefulness test (MWT) and Clinical Global Impression Improvement (CGI-I) rating in overall population (both P<0.001) subgroups participants taking concomitant stimulants P<0.05). Post-...