Since 2012, the WHO recommends lifelong ART with TDF+FTC/3TC+EFV for all HIV-positive pregnant and breastfeeding women (Option B-plus). In this analysis we describe the proportion of early and late transmission in mothers with high retention in Kampala, Uganda. We included 700 pregnant women from January 2012 to August 2014 with a follow-up extended to August 2016; the median age was 31 years (...

BACKGROUND Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, together we can") friends' psychosocial support intervention on clinical outcomes an...

Several studies have demonstrated an apparent link between positive selection on hematopoietic cells (HCs) and an "innate" T-cell phenotype. Whereas conventional CD8(+) T cells are primarily selected on thymic epithelial cells (TECs) and certain innate T cells are exclusively selected on HCs, MHC class Ib-restricted CD8(+) T cells appear to be selected on both TECs and HCs. However, whether TEC...

This report describes receptors for C4b on human peripheral B lymphocytes. The simultaneous presence of C3b and C4b receptors on the same lymphocytes was demonstrated by the formation of mixed rosettes consisting of the lymphocytes, EAC14 and EAC1423. Furthermore, reduction of the number of EAC1423 rosette-forming lymphocytes in a lymphocyte population by albumin gradient centrifugation concomi...

胃癌是最常见的消化道恶性肿瘤。已有研究表 明 ,中医药治疗可以增强癌症患者的免疫功能、减轻 放化疗的毒副反应、改善临床症状 , 不仅能提高远期 生存率 ,更重要的是能提高患者的生存质量 [ 1 ] 。 至精颗粒是张镜人教授研制的抗癌中药方 , 由 太子参、炒当归、灵芝草、黄精、淮山药、炒杜仲、白花 舌蛇草、蜀羊泉等中药组成。本临床研究结果显示 , 中药联合化疗组中医症状改善总有效率为68 .18% , 化疗 组为 43 .33% ; 中 药 联合 化 疗组 生存 质 量 ( Karnosfky 评分 ) 提高率 为 42 .04 %、降低 率为 9 .09 % ,化疗组生存质量提高率为 16 .67%、降低率 为 31 . 67% ; 中 药 联 合 化 疗 组 体 重 增 长 率 为 36 .36%、稳定率为 43 .18%、进展率为 20 .45% , 化 疗组体重增长率为 13...

Efforts in whole-genome sequencing and structural proteomics start to provide a global view of the protein universe, the set of existing protein structures and sequences. However, approaches based on the selection of individual sequences have not been entirely successful at the quantitative description of the distribution of structures and sequences in the protein universe because evolutionary ...

Evidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected individuals. However, the association between spontaneous proliferation and immunosuppress...

Pluripotent lymphohematopoietic stem cells are probably confined to bone marrow cells expressing CD34 surface molecules. To investigate the capacity of adult human CD34+ bone marrow cells to differentiate along the T lymphoid lineage, we plated purified CD34+ cells from healthy adults in liquid culture on adherent thymic stromal cells prepared from HLA- or blood group-mismatched postnatal thymi...