OBJECTIVES Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as metformin is widely used to regulate plasma glucose level and pomegranate and licorice have been identified to help in type-2 diabetes management. However, the interactions of the latter on metformin pharmacokinetics were not studied. Therefore, w...

Present study was performed to investigate the effect of Citrus limon and Pomegranate juices alone and their combinations on blood glucose and plasma insulin levels in alloxan induced diabetic rats as compared to diabetic control. Decrease in blood glucose level by Citrus limon was highly significant in dose dependant manner but there was highly significant increase in plasma insulin levels at ...

Although only recently Punica granatum (pomegranate) has been acclaimed for its health benefits, this fruit has long been cultivated and consumed, as a fresh fruit or in the form of beverage, especially in the Mediterranean region. In the present study, the antioxidant effects of the methanolic extract of pomegranate peels (MEPP) and pomegranate juice (PJ) were evaluated in normal male rats. Al...

BACKGROUND Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases the expression of oxidation-sensitive responsive genes (such as ELK-1 and p-CREB). Polyphenolic antioxidants contained in the juice derived from the pomegranate contribute to the reduction of oxidative stress and atherogenesis during disturbed shear stress. AIM OF THE STUDY ...

Prostate cancer is the second leading cause of cancer deaths in men in the United States. There is a major need for less toxic but yet effective therapies to treat prostate cancer. Pomegranate fruit from the tree Punica granatum has been used for centuries for medicinal purposes and is described as "nature's power fruit". Recent research has shown that pomegranate juice (PJ) and/or pomegranate ...

BACKGROUND Pomegranate fruit has been shown to exhibit the inhibitory activity against prostate cancer and lung cancer in vitro and in vivo, which might be a resource for chemoprevention and chemotherapy of cancer. Our previous documented findings indicated that treatment of urinary bladder urothelial carcinoma cell with the ethanol extract isolated from the juice of pomegranate fruit grown in ...

committee. Sequence identity between the three mature protein sequences is quite low, ranging from 66 to 68%. These isoforms demonstrated 62–65% sequence identity to Pru p 3. Interestingly, higher sequence identities were observed with Gossypium spp. (72%), Sorghum bicolor (67%) and Zea mays (66%). Although the study enrolled only a limited number of pomegranate-allergic patients (n = 6), surpr...

The public health burden of cardiovascular diseases (CVDs) is substantial. According to the World Health Organization report “The Global Burden of Disease” 2013 Update, heart diseases are expected to take the second place in the rank order of disease and injury burden by the year 2030 [1]. More than 50% reduction of CVD mortality is attributable to favourable changes in risk factors, while 43% ...

Pomegranate is an important source of several bioactive compounds with beneficial properties. As widely described in the literature, pomegranate can be considered as a functional food able to promote maintenance good health status. The present review article summarizes properties pomegranate, such antioxidant, anti?inflammatory, anti?aging, prebiotic and anticancer effects, well its protective ...

BACKGROUND AND THE PURPOSE OF THE STUDY Many drug substances along with a variety of naturally occurring dietary or herbal components interact with the CYP enzyme system. The present study was aimed to investigate the effect of pomegranate juice pre-treatment on the transport of carbamazepine across the rat intestine. METHODS The transport of carbamazepine across different parts of rat intest...