BACKGROUND The health benefits of pomegranate juice have been reported in several studies. However, limited clinical trials have examined the effects of concentrated pomegranate juice (CPJ) on inflammatory factors. OBJECTIVES This study aimed to investigate the effects of CPJ on metabolic risk factors, including inflammatory biomarkers, in patients with type 2 diabetes mellitus. PATIENTS AN...

This study was undertaken to evaluate the effect of pomegranate (Punica granatum, P.g.) juice on the oxidation state of the brain tissue of adult male albino rats and whether P.g. juice administration improves the activity of the antioxidant enzymes after carbon tetrachloride (CCl4) treatment as an oxidative stress agent. Rats were divided into four groups, Group I (control) was received intrap...

Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases the expression of oxidation-sensitive responsive genes (such as ELK-1 and p-JUN) in the endothelium. Evidence suggests that polyphenolic antioxidants contained in the juice derived from the pomegranate can contribute to the reduction of oxidative stress and atherogenesis. The aim of the ...

Background . Consumers consider pomegranate juice one of the most beneficial for health. The limited production pomegranates in Russia cannot meet needs Russian consumers with juices its own production. Pomegranate are produced from concentrates or pasteurized direct-squeezed imported different countries, there is no information about their antioxidant properties. Purpose Study content main bio...

Oxidative stress is associated with placental dysfunction and suboptimal pregnancy outcomes. Therapeutic interventions to limit placental injury from oxidative stress are lacking. Punicalagin is an ellagitannin and a potent antioxidant in pomegranate juice. We showed that both pomegranate juice and punicalagin decrease oxidative stress and apoptosis in cultured syncytiotrophoblasts. p53 is invo...

Aluminum is used as a stabilizer and effector in today's vaccine studies. Although aluminum all our lives, it has unsuitable properties terms of chemical properties. Pomegranate notable biological medicinal We aimed to measure biochemical parameters rat serum such electrolyte levels, kidney liver function test, lipid profile analyze the effects pomegranate juice towards AlCl3-induced hepato-nep...

Prostate cancer is dependent on circulating testosterone in its early stages and is treatable with radiation and surgery. However, recurrent prostate tumors advance to an androgen-independent state in which they progress in the absence of circulating testosterone, leading to metastasis and death. During the development of androgen independence, prostate cancer cells are known to increase intrac...

Angiogenesis is critical to tumor growth and is stimulated by tissue hypoxia due to poor oxygen delivery. In turn, cellular hypoxia leads to angiogenesis via the induction of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) at a cellular level. Pomegranate juice and extracts, which are rich sources of ellagitannins, have been shown to have chemopreventi...

Although there are no proven ways to delay onset or slow progression of Alzheimer's disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in different model systems. We asked whether dietary supplementation with pomegranate...