objectives: psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. the main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy plan and focus on its cost attributing measures, for a more reasonable quality of care program. methods: in this descriptive study, participants i...

The development of assays for plasma antiepileptic drug concentrations has led to the discovery of many pharmacokinetic interactions, some causing drug intoxication and others resulting in ineffective drug concentrations. In the 1970s, a number of epileptologists began to argue that single drug therapy was desirable in the treatment of epilepsy and this has become the accepted policy when initi...

OBJECTIVE To examine the outcomes of children receiving dexmedetomidine after single-stage airway reconstruction. STUDY DESIGN Historical cohort study. SETTING Tertiary care children's hospital. SUBJECTS AND METHODS Of 61 eligible patients, 50 children undergoing single-stage airway reconstruction were included in the study. Thirty children received dexmedetomidine (Dex) as a primary seda...

BACKGROUND Clinical guidelines advise against prescribing more than one antipsychotic with limited exceptions. Despite this, surveys continue to report high antipsychotic polypharmacy rates. The aim of the study was to investigate the effectiveness of a multi-faceted intervention in reducing prescribing of antipsychotic polypharmacy on general adult psychiatry wards, compared with guidelines al...

Background. Despite recommendations by guidelines to avoid combinations of antipsychotics unless after multiple trials of antipsychotic monotherapy, it is quite a common practice to use combinations. This practice leads to unnecessary expenses and exposes the patient to severe drug adverse effects. Methods. An institution based cross-sectional study was conducted from April to May 2014. Systema...

Background: Polypharmacy is the use of five or more types drugs in a therapy simultaneously. The polypharmacy increases potential for drug-drug interactions. In COVID-19 therapy, varied antiviral and non-antiviral medications allow increased drug Objective: To determine relationship between interactions therapy. Method: This an analytical observational study with retrospective data retrieval us...

BACKGROUND The use of multiple medicines (polypharmacy) is increasingly common in older people. Ensuring that patients receive the most appropriate combinations of medications (appropriate polypharmacy) is a significant challenge. The quality of evidence to support the effectiveness of interventions to improve appropriate polypharmacy is low. Systematic identification of mediators of behaviour ...

BACKGROUND Numerous methods have been used to evaluate medication management quality in older adults; however, their predictive validities are unknown. Major medication quality indicators include polypharmacy, drug-drug interactions, and inappropriate medication use. To date, no study has attempted to evaluate the three approaches systematically or the effect of each approach on mortality in a ...

Background: In psychiatry, polypharmacy is more the rule than the exception. The present study investigates the frequency and type of polypharmacy in various diagnostic groups amongst patients of a psychiatric outpatient care unit. Methods: Patients’ medical records were used to collect data on the last psychopharmacological medication prescribed in 2005 for all patients at the outpatient care ...

Xerostomia is defined as the perception of dry mouth, and dysgeusia, a change in taste. Both are common complaints elderly, especially among those making use polypharmacy drug combinations. Aim: This study aimed to determine prevalence xerostomia dysgeusia investigate their association with elderly. Methods: older people under follow-up at Multidisciplinary Elderly Center University Hospital Br...