Two highly convergent syntheses of a fully protected C1-C19 polyol subunit of the brasilinolide family of immunosuppressive macrolides are described, exploiting boron-mediated 1,5-anti aldol couplings to form the C8-C9 and C13-C14 bonds.

With diabetes reaching epidemic proportions, there is an urgent need for reliable treatment strategies for microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular (coronary heart disease and stroke) diabetes complications. The role of diabetic hyperglycemia in the development of complications has been extensively studied and a number of biochemical pathways activated by hyper...

To obtain the optimal 1:1 composition of FePt alloy nanomaterials by polyol synthesis, the iron precursor (iron pentacarbonyl, Fe(CO)5) must be used in excess, because the Fe(CO)5 exists in the vapor phase at the typical temperatures used for FePt synthesis and cannot be consumed completely. Fabrication of Fe3O4 nanoparticles by consuming the excess iron precursor was an effective strategy to m...

A new method for the synthesis of lignin-based liquid polyols was developed. Organosolv lignin reacted with ethylene carbonate in polyethylene glycol as solvent, leading to a full conversion phenolic OH into primary aliphatic groups. These aromatic are obtained single step, without any purification. Upon modification molar mass, wide range hydroxyl values (IOH) can be covered. The up 30%wt have...

Abstract By partially substituting 1,3,5-tris-(2-hydroxyethyl) cyanuric acid for glycerol as the polyol, new modified alkyd resins having a wide range of oil length and hydroxyl content were produced. FT-IR, 1 H NMR, iodine values, other characterization techniques used to confirm chemical compositions resins. The drying qualities synthesized significantly enhanced by adding greater quantity fr...

Many of the advances in material performance over the last decade can be attributed to developments in multicomponent polymer systems and specifically, to multiphase materials such as incompatible polymer blends and fibre-reinforced composites. In these types of material, performance properties are often dominated by the interphase that defines the transition region from one pure phase to anoth...

Cd(OH)2 nanobelts have been synthesized in high yield by a convenient polyol method for the first time. XRD, XPS, FESEM, and TEM were used to characterize the product, which revealed that the product consisted of belt-like crystals about 40 nm in thickness and length up to several hundreds of micrometers. Studies found that the viscosity of the solvent has important influence on the morphology ...

Six non-glucose polyols--mannose, fructose, 1-deoxyglucose, mannitol, glucitol, and inositol--were identified and evaluated in human serum and cerebrospinal fluid by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Concentrations of fructose, mannose, and inositol in the serum of healthy persons or children without metabolic diseases varied with age, as already repo...

A low cost, abundant, and renewable vegetable oil source has been gaining increasing attention due to its potential to be chemically modified to polyol and thence to become an alternative replacement for the petroleum-based polyol in polyurethane production. In this study, jatropha oil-based polyol (JOL) was synthesised from non-edible jatropha oil by a two steps process, namely epoxidation and...

Novel polyols were synthesized by controlled polymerization of hydroxylated fatty acids from methyl soyate. Polymerization of methyl esters of hydroxy fatty acids gives a hyperbranched (HB) product with different content of hydroxyl groups depending on the degree of conversion. Molecular weights, functionality and hydroxyl equivalent of polyols can be controlled by controlling the degree of con...