نتایج جستجو برای: polyketide synthase gene

تعداد نتایج: 1200120  

2016
Hyang Yeon Kim Do Yeon Heo Hye Min Park Digar Singh Choong Hwan Lee Kyoung Heon Kim

Penicillium spp. are known to harbor a wide array of secondary metabolites with cryptic bioactivities. However, the metabolomics of these species is not well-understood in terms of different fermentation models and conditions. The present study involved metabolomics profiling and transcriptomic analysis of Penicillium expansum 40815 under solid-state fermentation (SSF) and submerged fermentatio...

1998
Kevin A. Reynolds

Polyketides produced by bacteria and fungi represent an extremely rich source of biologically active compounds that find wide-ranging applications as antibiotics, immunosuppresants, antitumor agents, and antiparasitic agents. The striking structural diversity of polyketides that gives rise to these wide-ranging applications is dictated both by the polyketide synthase (PKS) responsible for assem...

Journal: :The Journal of biological chemistry 2010
Zhe Rui Katerina Petrícková Frantisek Skanta Stanislav Pospísil Yanling Yang Chung-Yung Chen Shih-Feng Tsai Heinz G Floss Miroslav Petrícek Tin-Wein Yu

Asukamycin, a member of the manumycin family metabolites, is an antimicrobial and potential antitumor agent isolated from Streptomyces nodosus subsp. asukaensis. The entire asukamycin biosynthetic gene cluster was cloned, assembled, and expressed heterologously in Streptomyces lividans. Bioinformatic analysis and mutagenesis studies elucidated the biosynthetic pathway at the genetic and biochem...

2007
Ocky Karna Radjasa Jutta Wiese

In this study we examined marine bacteria associated with different corals (Porites lutea, Galaxea fascicularis, Acropora sp. and Pavona sp.) collected from vicinity of Panjang island, Jepara, North Java Sea, Indonesia for their antimicrobial activities against the bacteria Echerichia coli, Bacillus subtilis, Staphylococcus lentus and the yeast Candida glabrata. A total of 13 bacterial isolates...

Journal: :Chembiochem : a European journal of chemical biology 2010
Seok Joon Kwon Moon Il Kim Bosung Ku Lydie Coulombel Jin-Hwan Kim Joseph H Shawky Robert J Linhardt Jonathan S Dordick

Receptor tyrosine kinases are critical targets for the regulation of cell survival. Cancer patients with abnormal receptor tyrosine kinases (RTK) tend to have more aggressive disease with poor clinical outcomes. As a result, human epidermal growth factor receptor kinases, such as EGFR (HER1), HER2, and HER3, represent important therapeutic targets. Several plant polyphenols including the type I...

2016
Brian Lowry Xiuyuan Li Thomas Robbins David E. Cane Chaitan Khosla

Vectorial polyketide biosynthesis on an assembly line polyketide synthase is the most distinctive property of this family of biological machines, while providing the key conceptual tool for the bioinformatic decoding of new antibiotic pathways. We now show that the action of the entire assembly line is synchronized by a previously unrecognized turnstile mechanism that prevents the ketosynthase ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید