Regional cerebral blood flow was measured repeatedly in anesthetized and immobilized cats under various experimental conditions by recording the clearance of inhaled hydrogen with inserted platinum electrodes and by recording the distribution of 15 mu microspheres labeled with 3 different radioisotopes. The values for both methods in normal cortical tissue were comparable (75.7 +/- 23.5 ml/100 ...

A computer modeling approach for constructing a three-dimensional microsphere-packed bone graft structure is presented. The modeling approach consists of both geometric and CAD-based computer modeling. The geometric model uses two extreme microsphere packing models (minimum-density packing and maximum-density packing) and a statistical packing model to determine the number of microspheres packe...

To improve the in vivo resorption of an injectable calcium phosphate cement (CPC) for bone tissue engineering purposes, in previous experiments macroporosity was introduced by the in situ degradation of incorporated gelatin microspheres. Gelatin microspheres are also suitable carriers for osteoinductive drugs/growth factors, where release occurs concomitantly with degradation of the hydrogel. I...

BACKGROUND AND PURPOSE Information on sustained damage to cerebral function and metabolism after cerebral ischemia is useful for prophylaxis and therapeutics of cerebral infarction. The purpose of the present study was to induce sustained damage to brain regions after cerebral ischemia in experimental animals. For this purpose, we examined animal behavior and cerebral energy metabolism followin...

BACKGROUND AND PURPOSE An experimental model that induces sustained ischemia and infarction may provide useful information relevant to prevention of the development of ischemic brain disease. The purpose of the present study was to elucidate the pathophysiological consequences of cerebral blood flow under sustained cerebral ischemia or oligemia and infarction in rats after microsphere embolism....

objective(s): the purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (ba) enhancement of potent sulfonamide- type loop diuretic- furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. the comparatively poor and inconstant b...

Src homology 2 (SH2) domains are evolutionary conserved small protein modules that bind specifically to tyrosine-phosphorylated peptides. More than 100 SH2 domains have been identified in proteins encoded by the human genome. The binding specificity of these domains plays a critical role in signaling within the cell, mediating the relocalization and interaction of proteins in response to change...

OBJECTIVES To evaluate the impact of correcting myocardial signal saturation on the accuracy of absolute myocardial blood flow (MBF) measurements. MATERIALS AND METHODS We performed 15 dual bolus first-pass perfusion studies in 7 dogs during global coronary vasodilation and variable degrees of coronary artery stenosis. We compared microsphere MBF to MBF calculated from uncorrected and correct...

The presence of heavy metals in the environment as a consequence human activity is an issue that has caught attention researchers to find wastewater treatment solutions, such adsorption. In this work, hydrochars and activated carbon microspheres are prepared from tangerine peels precursor FeCl3 activating structure-directing agent hydrothermal carbonization, allowing obtain hydrochar ranging 50...