62 cases of polycystic ovary syndrome (PCO) were reviewed with regards to their clinical and endocrine features. The subgroup of patients with acanthosis nigricans (AN) was further studied in detail. The prevalence of the syndrome was significantly higher in the Indian (35.5% of cases). Obesity, AN, hirsuitism, non-insulin dependent diabetes mellitus (NIDDM) and raised level of serum testostero...

BACKGROUND Metformin is effective for the treatment of polycystic ovary syndrome, but conflicting results regarding its effect on adipocytokine levels (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving metformin treatment have been reported. To provide high-quality evidence about the effect of metformin treatment on adipocytokines in patients with...

OBJECTIVE To compare lipid profile in lean and obese women with polycystic ovary syndrome with normal weight and obese controls. METHOD The case-control study was conducted at the Department of Chemical Pathology, Liaquat National Hospital, Karachi, from March 2006 to April 2007. It comprised 50 cases of polycystic ovary syndrome along with 50 healthy controls matching for age, gender and wei...

AIM OF THE STUDY to determine the effect of rosiglitazone on plasma adiponectin and resistin levels in obese, non-diabetic polycystic ovary (PCO) subjects and relationship between circulating adipocytokines, insulin resistance and lipid profile. MATERIAL AND METHODS PCOS women were treated 6 months with 4mg rosiglitazone daily (the blood was tested before and 3; 6 months after treatment). Pla...

Women with polycystic ovary syndrome are characterized by obesity, menstruation irregularity, hirsutism and infertility, and prevalent with cardiometabolic comorbidities, but population-based studies on the risk of developing coronary artery disease are limited. From claims data of the Taiwan National Health Insurance, we identified 8048 women with polycystic ovary syndrome aged 15-49 years new...

background: some studies propose that changes in leptin concentrations (above or under the normal range) result in infertility. therefore, we investigated serum and follicular fluid leptin concentrations in infertile women with polycystic ovary syndrome (pcos). objective: to study serum and follicular fluid leptin concentrations in infertile women with pcos. materials and methods: we conducted ...

objective: exercise activity could be an amendment to polycystic ovary syndrome (pcos). however the acute and chronic effects of various exercise intensities on serum leptin levels are ambiguous. this study investigates the acute and chronic responses of various intensities of exercise on serum leptin levels and weights of female rats with pcos. methods: in this semi-empirical study, 80 adult w...

Due to genetic heterogeneity and variable diagnostic criteria, genetic studies of polycystic ovary syndrome are particularly challenging. Furthermore, lack of sufficiently large cohorts limits the identification of susceptibility genes contributing to polycystic ovary syndrome. Here, we carried out a systematic search of studies deposited in the Gene Expression Omnibus database through August 3...