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BACKGROUND AND AIM: Per- and polyfluoroalkyl substances (PFAS) polybrominated diphenyl ethers (PBDEs) are endocrine disrupting chemicals associated with reproductive toxicity adverse health outcomes, including certain cancers. PFAS PBDEs may affect through alternations in telomere length. We examined joint associations between prenatal exposure to PFAS, PBDEs, maternal newborn length using mixt...

Recent progress has been made in the reductive debromination of polybrominated diphenyl ethers (PBDEs) by nanoscale zero-valent iron (nZVI). To better understand the mechanism of this reaction, seven selected BDE congeners and their anions were investigated at the density functional theory (DFT) level using four different methods, including B3LYP/6-31G(d), B3LYP/6-31+G(d), B3LYP/6-31G(d,p) and ...

Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a gene...

We analyzed polybrominated diphenyl ethers (PBDEs) in abdominal adipose of oceanic seabirds (short-tailed shearwaters, Puffinus tenuirostris) collected in northern North Pacific Ocean. In 3 of 12 birds, we detected higher-brominated congeners (viz., BDE209 and BDE183), which are not present in the natural prey (pelagic fish) of the birds. The same compounds were present in plastic found in the ...

Introduction. Polybrominated diphenyl ethers (PBDEs) are currently the most widely studied class of additive brominated flame retardants (BFRs) that have been shown to bioaccumulate in wildlife and humans (Hites 2004). There are an increasing number of reports on PBDEs in top predator avian species (Norstrom et al. 2002; Verreault et al. 2005; McKinney et al. 2006). Specifically, the North Amer...

Levels of polybrominated diphenyl ethers (PBDEs) measured in human samples have increased in recent years, but the health effects of these compounds are not well studied. A group of persistent pol­ lutants similar in structure to polychlorinated biphenyls (PCBs), PBDEs are thought to affect endocrine function, but this relation­ ship has only been examined in several small studies. A new study ...

This review surveys the recent literature on the neurodevelopmental impacts of chemical exposures during pregnancy. The review focuses primarily on chemicals of recent concern, including phthalates, bisphenol-A, polybrominated diphenyl ethers, and perfluorinated compounds, but also addresses chemicals with longer histories of investigation, including air pollutants, lead, methylmercury, mangane...

Polybrominated diphenyl ethers (PBDEs) have been identified in every compartment of the environment and biota due to their widespread use as flame retardants. There is debate over their potential to threaten environmental and human health due to insufficient toxicological information. The weak to moderate binding affinity of PBDE congeners to the Ah receptor (AhR) and the weak induction of EROD...