• Salt permeability of polyamide RO membranes is invariant in a wide salinity range. The solution diffusion model adequately describes our seawater membranes. Membrane leaks may cause correlation between and observed salt permeability. New developments modeling solute transport reverse osmosis (RO) are based on the mechanistic description friction electromigration. In these models, membrane cha...

Thin-film composite (TFC) membranes show great potential in dye nanofiltration but their performance still required further improvement. In this work, ultra-small EMT zeolite nanocrystals were embedded into the interfacial polymerized polyamide (PA) layer supported on porous nylon via spray dispersion method and used separation. Ultra-small nanosized crystals with plate-like morphology synthesi...

This study elucidates the relationship between membrane properties and the rejection of trace organic contaminants (TrOCs) in forward osmosis (FO). An asymmetric cellulose triacetate (CTA) and a thin-film composite (TFC) polyamide FO membrane were used for this investigation. The effective average pore radius (rp), selective barrier thickness over porosity parameter (l/ε), surface charge, suppo...

We recently developed a new type of pyrrole (Py)-imidazole (Im) polyamide-tetrahydrocyclopropabenzindolone (CBI) conjugate with an indole linker as a stable sequence-specific alkylating agent. In this study, we investigated the gene silencing activities of polyamides A, B and C, which selectively alkylate specific sequences in the promoter region, non-coding strand and coding strand, respective...

This research investigated the direct bonding mechanism of dissimilar materials such as metals and plastic by the conventional hot pressing process. The press area of 4 x 4 mm2 was used for direct bonding. The results of the study showed that titanium was completely bonded to polyamide 66. On the other hand, titanium was not bonded to polystyrene. In the case of bonding material of titanium wit...

Abstract This study endeavors to augment the antibacterial and anti‐biofouling properties of thin‐film composite polyamide membranes by subjecting them modification with chitosan silver nanoparticle materials through UV‐induced graft polymerization technique. Various surface assessment methods were employed, efficiency membrane performance was demonstrated flux retention filtration process, whi...

Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of DNA-binding small molecules on hypoxia-inducible transcription of VEGF. A synthetic pyrrole-imidazole polyamide designed to bind the hypoxia response element (HRE) was found to disrupt hypoxia-inducible factor (HIF) b...

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significantly downregulates AR driven gene expression. Polyamide exposure to VCaP cells reduced proliferat...

A method for harvesting and purifying the thin polyamide (PA) active layer from thin-film composite (TFC) reverse osmosis (RO) membranes was developed, enabling quantitative nuclear magnetic resonance (NMR) measurements of composition cross-linking in PA that can be directly related to membrane performance. Using our chemical separation process, we report on four trimesoyl chloride (TMC)/isopht...

Polyamide matrices, such as membranes, gels and non-wovens, have been applied as supports for enzyme immobilization, although in literature he enzyme immobilization on woven nylon matrices is rarely reported. In this work, a protocol for a Trametes hirsuta laccase immobilization sing woven polyamide 6,6 (nylon) was developed. A 24 full factorial design was used to study the influence of pH, spa...