OBJECTIVE Dark poly(caprolactone) trifumarate is a successful candidate for use as a bone tissue engineering scaffold. Recently, a white polymeric scaffold was developed that shows a shorter synthesis time and is more convenient for tissue-staining work. This is an in vitro comparative study of both the white and dark scaffolds. METHODS Both white and dark poly(caprolactone) trifumarate macro...

Asymmetric telechelic α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone) (HA-PCL), α-hydroxyl-ω-(benzylic ester)-poly(ε-caprolactone) (HBz-PCL) and an asymmetric telechelic copolymer α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone-co-γbutyrolactone) (HA-PCB) were synthesized by ring-opening polymerization of εcaprolactone (CL). CL and CL/γ-butyrolactone mixture were used to obtain homopolym...

In vitro cell culture is traditionally performed within two-dimensional (2D) environments, providing a quick and cheap way to study cell properties in a laboratory. However, 2D systems differ from the in vivo environment and may not mimic the physiological cell behavior realistically. For instance, 2D culture models are thought to induce cancer stem cells (CSCs) differentiation, a rare cancer c...

Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T1/T2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this st...

This paper describes the utilization of Proton-Nuclear Magnetic Resonance spectroscopy ((1)H NMR) to quantify the stoichiometric ratios between poly (ε-caprolactone) [PCL] and α-cyclodextrin (α-CD) present in their non-stoichiometric inclusion complexes [(n-s)-ICs]. This paper further describes the porosity and fiber alignment of PCL nanofibers nucleated by the [(n-s)-ICs] during electrospinnin...

Antioxidant capacity of poorly soluble natural antioxidant kaempferol, in particular free or loaded two types cationic micelles, was studied on non-enzyme induced lipid peroxidation (LPO) vitro . The micelles were based triblock copolymers - poly(2-(dimethylamino)ethyl methacrylate-b-poly(propylene oxide)-b-poly(2-(dimethylamino)ethyl methacrylate (PDMAEMA-PPO-PDMAEMA) and methacrylate-b-poly(ε...

Patterned coatings based on biodegradable crosslinked poly(ester/carbonate) have been prepared by photo-induced ring-opening polymerization of a liquid bifunctional trimethylene carbonate-based monomer using poly(ε-caprolactone) triol as initiator and guanidine superbase photogenerator activated irradiation at 385 nm. The influence various parameters gel time such components molar ratios, or re...