A numerical study is presented to investigate the electronic transport properties through a synthetic DNA molecule based on a quasiperiodic arrangement of its constituent nucleotides. Using a generalized Green's function technique, the electronic conduction through the poly(GACT)-poly(CTGA) DNA molecule in a metal/DNA/metal model structure has been studied. Making use of a renormalization schem...

The title compound, [Na(C(16)H(36)BO(4))](n), has a fourfold axis passing through the Na and B atoms which both are bound by four O atoms. The tetra-butoxy-borate anion provides the bridging to form one-dimensional polymers running along [001], just like those found for the tetra-ethoxy-borate structure. The two but-oxy 'tail' atoms are disordered over two conformations in a 0.887 (9):0.113 (9)...

BACKGROUND DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase I belongs to the family of poly(ADP-ribose)-binding proteins and is the target of camptothecin derived anticancer drugs. Poly(ADP-ribosyl)ation occurs at specific sites of the enzyme inhibiting the cleavage and enhancing the religation s...

Maternal immune activation (MIA) resulting from prenatal exposure to infectious pathogens or inflammatory stimuli is increasingly recognized to play an important etiological role in neuropsychiatric disorders with neurodevelopmental features. MIA in pregnant rodents induced by injection of the synthetic double-stranded RNA, Poly I:C, a mimic of viral infection, leads to a wide spectrum of behav...

Isothermal phase diagrams for the semicrystalline poly-L-lactide (PLLA) and the amorphous poly-DL-lactide (PDLLA) in combination with several solvent-nonsolvent combinations (dioxane/water, dioxane/methanol, chloroform/methanol, and NMP/water) have been determined. The locations of the liquid-liquid miscibility gap, the solid-liquid miscibility gap and the vitrification boundary in the isotherm...

The author would like to express his appreciation to Professor Ephraim Katchalski for his hospitality, to Professor Michael Sela for samples from his collection and for valuable discussion, to Professor Franz Sondheimer for the use of a spectrophotometer, and to Dr. Israel Schechter and Mr. Shmuel Shaltiel for valuable advice. Abbreviations used are: pTR, poly-L-tyrosyl ribonuclease; pApTR-L, l...

In the centrosymmetric title compound, [Ag(4)(C(10)H(2)O(8))](n), the benzene ring has irregular bond lengths but remains planar (r.m.s. deviation 0.0002 Å). The Ag-O bond lengths are in the range 2.153 (3)-2.615 (4) Å. The carboxyl-ate groups are oriented at dihedral angles of 26.4 (5) and 74.9 (4)° to the benzene ring. The coordination behaviour of each carboxyl-ate O atom is different: in on...

The crystal structure of the title compound, [Cu(C(2)N(3))(C(2)H(3)N)(2)](n), features zigzag chains along the a axis that consist of alternating [Cu(MeCN)(2)] and dicyanamide units, the latter acting as bidentate ligands via both terminal N atoms. The Cu atom shows a slightly distorted tetra-hedral coordination sphere. The anionic and neutral ligands lie on different mirror planes (perpendicul...

A total of 40 mouse-human cell hybrids were induced with poly(I).poly(C) and with Newcastle disease virus. Ten hybrid clones produced low levels of human interferon in response to both the virus and poly(I).poly(C). Concurrent enzymic and chromosomal analysis of the hybrid clones indicated a concordant segregation of these levels of human interferon with chromosomes 2 and 5. The presence of bot...