γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer's disease (AD). Despite considerable interest in developing γ-secretase targeting therapeutics for the treatment of AD, the precise mechanism by which γ-secretase produces Aβ has remained elusi...

The dynamic nature of protein structures provides challenges and opportunities for ligand design. I will first discuss some of the different ways in which protein dynamics can be targeted, giving examples from our experience in the design of inhibitors of thymidylate synthase [1-3]. I will then describe the development of a computational toolbox (TRAPP: TRAnsient Pockets in Proteins) to identif...

Because current remote monitor systems can’t deal with problems of real-time transmissions in the bad condition of network very well, this article presents a study which is combined with the evaluation of video streams, adjustment and sealing user-defined data pockets and discarding useless data pockets. The goal of this solution is to transmit video information of national grain depot. And its...

Background: PfEBA-140 recognizes sialic acid on its receptor Glycophorin C during erythrocyte invasion. Results: PfEBA-140 contains two sialic acid binding pockets distinct from other sialic acid binding proteins and with divergent roles in receptor recognition. Conclusion: The glycan binding pockets define receptor recognition, specificity, and putative switching. Significance: The first detai...

This paper deals with secondary cooling in a continuous caster. In particular, it inhomogeneity caused by spray arrangement and segmented rolls used for leading the strand. The section is placed under mold. Segmented are supported bearings several places across Sprayed water can flow gaps between where bearing pocket located. main question that was experimentally studied how this geometry influ...

Single-layer FeSe films with an extremely expanded in-plane lattice constant of 3.99±0.02  Å are fabricated by epitaxially growing FeSe/Nb:SrTiO3/KTaO3 heterostructures and studied by in situ angle-resolved photoemission spectroscopy. Two elliptical electron pockets at the Brillouin zone corner are resolved with negligible hybridization between them, indicating that the symmetry of the low-ener...

The electronic momentum distribution n(k) of the two dimensional Hubbard model is studied for different values of the coupling U/t, electronic density 〈n〉, and temperature, using quantum Monte Carlo techniques. A detailed analysis of the data on 8× 8 clusters shows that features consistent with hole pockets at momenta k = (±π2 ,± π 2 ) appear as the system is doped away from half-filling. Our r...

Electron microscopy of the cells of the thermogenic appendix of Sauromatum guttatum has revealed a fusion event between pocket-like structures of the rough endoplasmic reticulum (rER) and the plasma membrane. As a result of the fusion event, many regions of the plasma membrane have paired unit membranes (four leaflets instead of two). The fusion allows the transfer of osmiophilic material from ...

Demand for electric power typically depends on the temperature and several other weather factors. It also depends on the day of the week and the hour of the day. This paper models electric power demand for close geographic areas that are called load pockets. We have developed a statistical model for load pockets. This model describes the load during the summer period. In this model we took into...