Pneumocysis jirovecii pneumonia (PJP) is a type of originating from the fungus Pneumocystis jiroveci and major cause serious in immunocompromised conditions. PJP typically appears as bilateral diffuse pulmonary infiltrates. Granulomatous an uncommon form pneumocystis infection, occurring only 3% to 5% patients. Calcification exceptional. We present 9-month-old boy affected by Severe Combined Im...

Although acquired bone marrow failure (BMF) is considered a T cell-mediated autoimmune disease, few studies have considered contributing roles of innate immune deviations following otherwise innocuous infections as a cause underlying the immune defects that lead to BMF. Type I IFN signaling plays an important role in protecting hematopoiesis during systemic stress responses to the opportunistic...

OBJECTIVES To determine the rate and identify risk factors of Pneumocystis jirovecii (P. jirovecii) colonization among patients with systemic autoimmune diseases. METHODS We conducted an observational study in patients with systemic autoimmune diseases in an internal medicine department. Each week, five patients with systemic diseases were randomly selected for colonization screening. Patient...

Pneumocystis pneumonia (PcP) is a significant cause of morbidity and mortality in immunocompromised patients. In humans, PcP is caused by the opportunistic fungal species Pneumocystis jirovecii. Progress in Pneumocystis research has been hampered by a lack of viable in vitro culture methods, which limits laboratory access to human-derived organisms for drug testing. Consequently, most basic dru...

Pneumocystis pneumonia (PCP) is a major cause of morbidity and mortality in patients with HIV infection. CD4(+) T lymphocytes are critical for host defense against this infection, but in the absence of CD4(+) T lymphocytes, CD8(+) T lymphocytes may provide limited host defense. The cytokine interleukin-7 (IL-7) functions to enhance lymphocyte proliferation, survival, and recruitment of immune c...

chronic obstructive pulmonary disease (copd) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

Almeida et al. (1) have interrogated the genomes of two Pneumocystis species, Pneumocystis jirovecii and its sister Pneumocystis carinii, for genes known to be involved in sexual reproduction in the widely studied fission yeast Schizosaccharomyces pombe, with the hope that defining genetic pathways governing sexual reproduction in Pneumocystis will inform disease prevention strategies. Pneumocy...

La aspergilosis pulmonar invasiva es una enfermedad presente principalmente en pacientes inmunocomprometidos con alta carga de mortalidad. neumonía por Pneumocystis jirovecii infección oportunista potencialmente mortal que afecta a diversas etiologías. coinfección estos patógenos inmunocompetentes inusual. Reportamos un caso paciente sin las causas tradicionales inmunocompromiso el desarrollo A...

A case of Pneumocystis carinii pneumonia developing a patient with treated diffuse lymphocytic lymphoma is described. The electron microscopic features and life cycle of the organism are illustrated. The patient died twenty-four hours after the biopsy had been taken. Septrin appeared to have affected the trophozoite stage. Pneumocystis carinii appears to induce interstitial pulmonary oedema and...