نتایج جستجو برای: pmn

تعداد نتایج: 3528  

Journal: :Infection and immunity 2005
Mark P Simons William M Nauseef Michael A Apicella

Neisseria gonorrhoeae causes severe exudative urethritis. The exudates from infected individuals contain large numbers of polymorphonuclear leukocytes (PMN) with ingested gonococci. The fate of N. gonorrhoeae within PMN has been a topic of debate for years. In this study, we examined the interactions of N. gonorrhoeae with PMN adherent to surfaces as a system that better models events during cl...

Journal: :Environmental Health Perspectives 2003
David J Tenenbaum

Objectives: Steroids, used in preterm premature ruptureof membranes (pPROM), to reduce the risk of morbidity and mortality of the preterm neonate, impair the maternal polymorphonuclear leukocyte (PMN)-based immune system. In spite of combination with antibiotics, prenatal and postnatal bacterial infections of mother and child are frequent. This pilot study focuses on the influence of steroids i...

Journal: :The Journal of clinical investigation 1983
C A Dahinden J Fehr T E Hugli

The complement-derived anaphylatoxin C5a and a putative analogue of bacterial chemotactic factor (N-formyl-methionyl-leucyl-phenylalanyl [fMLP]), as well as bacterial lipid A, all stimulate human granulocyte (PMN) adhesiveness and superoxide (O-2) production in a concentration-dependent manner. Since attachment of particulate matter to the PMN membrane is an early event in the triggering of res...

Journal: :Antioxidants 2021

Jenny shows a large endometrial reaction after semen influx to the uterus with amount of polymorphonuclear neutrophils (PMN) migrating into uterine lumen. PMN act as sperm selection mechanism through phagocytosis and NETosis (DNA extrudes and, together proteins, trap spermatozoa). While reduced percentage spermatozoa are phagocytosed by PMN, most found be attached neutrophil extracellular traps...

Journal: :Blood 1984
T A Lane G E Lamkin

We investigated the effect of a candidate artificial blood substitute, Fluosol-DA (FDA), on human neutrophil function in a serum-free medium. In a 50% (vol/vol) mixture with polymorphonuclear cells (PMN), FDA had no effect on PMN viability, phagocytosis, superoxide anion generation, degranulation, or bactericidal activity. In striking contrast, the random migration and chemotaxis of PMN to both...

Journal: :Journal of immunology 2000
E J Campbell M A Campbell C A Owen

Although proteinase 3 (PR3) is known to have the potential to promote inflammation and injure tissues, the biologic forms and function of PR3 in polymorphonuclear neutrophils (PMN) from healthy donors have received little attention. In this paper, we show that PMN contain 3.24 +/- SD 0.24 pg of PR3 per cell, and that the mean concentration of PR3 in azurophil granules of PMN is 13.4 mM. Low lev...

Journal: :The American journal of physiology 1997
S F Van Eeden S Bicknell B A Walker J C Hogg

We recently reported that L-selectin expression increases on circulating polymorphonuclear leukocytes (PMN) during active bone marrow release, which suggests that older cells in the circulation have lower levels of L-selectin than those recently released from the bone marrow. The present study was designed to test the hypothesis that L-selectin expression reduces on PMN as they age in the circu...

Journal: :The Journal of biological chemistry 2011
Celia X-J Chen Ileana Soto Ya-Lan Guo Yuan Liu

Neutrophil (polymorphonuclear leukocyte; PMN) inflammatory functions, including cell adhesion, diapedesis, and phagocytosis, are dependent on the mobilization and release of various intracellular granules/vesicles. In this study, we found that treating PMN with damnacanthal, a Ras family GTPase inhibitor, resulted in a specific release of secondary granules but not primary or tertiary granules ...

Journal: :The Tokai journal of experimental and clinical medicine 1992
K Mishima Y Ichikawa H Shimizu M Yoshida S Arimori

Cell surface antigens, such as CR3, Fc gamma RIII, cALLa and Leu 8 antigen, expressed on polymorphonuclear cells (PMN) in the peripheral blood (PB) are associated with certain functions of PMN. Functional alterations of PMN have been reported in some rheumatic diseases. In this study, therefore, the cell surface antigens were examined by 2-color flow-cytometry using monoclonal antibodies to cla...

Journal: :The Journal of biological chemistry 2001
Y Liu D Merlin S L Burst M Pochet J L Madara C A Parkos

CD47, a cell surface glycoprotein, plays an important role in modulating neutrophil (PMN) migration across endothelial and epithelial monolayers. Here we show that anti-CD47 monoclonal antibodies (mAbs) delay PMN migration across collagen-coated filters or T84 epithelial monolayers toward the chemoattractant formylmethionylleucylphenylalanine (fMLP). Despite delayed transmigration by anti-CD47 ...

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