Tongue squamous cell carcinoma (TSCC) is the most common malignancy in oral and maxillofacial tumors with highly metastatic characteristics. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone; PLB), a natural naphthoquinone derived from the roots of Plumbaginaceae plants, exhibits various bioactivities, including anticancer effects. However, the potential molecular targets and underlying mechani...

Over the past few decades there has been much interest in natural materials as sources of new antibacterial agents. Different extracts from traditional medicinal plants have been tested. Many reports show the effectiveness of traditional herbs against microorganisms; as a result, plants have become one of the bases of modern medicine (Evans et al., 2002). Plants have given the Western pharmacop...

Background: Acantholimon gilliati Turril(Plumbaginaceae) is used in variety of diseases including hepatic ailments in the west region of Iran. Aim of the study: To investigate the hepatoprotective effect of methanoilc extract (ME) of A. gilliati on formaldehyde (FA) induced liver injury in adult male mice.Materials and methods: Fifty six adult male mice were divided into 8 groups. In control gr...

OBJECTIVE Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae), has been extensively studied for its pharmacological activities and reported to show a good anti-cancer activity in different human cancer cell lines. It is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. Plumbagin is also known to inhibit NF-κB, JNK (Hsu), PKCε...

Medicinal plants are one of the important sources of natural products, which include essential oils, fragrances, pigments, feedstock, and pharmaceuticals. They are of great interest to the researches in biotechnology field as most of the pharmaceutical industries depend on them Chand et al. [1]. Plumbago zeylanica is an important medicinal plant which belongs to the Plumbaginaceae family. It is...

in the present study, plumbago zeylanica linn. (plumbaginaceae) , one of the folk medicinal plants commonly used as antifertility agent was evaluated for its antifertility effect. five successive solvent extracts, petroleum ether, chloroform, acetone, ethanol and water extracts, of the stems of p. zeylanica were studied on estrous cycle at two dose levels, 200 and 400 mg/kg respectively.   of t...