The synaptic organization of dopamine-containing amacrine cells in the rhesus monkey retina was studied using immunohistochemistry of tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthetic pathway. Cell bodies of the TH-containing neurons were primarily in the innermost tier of the inner nuclear layer. Their synaptic processes, confined to the outermost stratum of th...

PURPOSE The hallmark of neurofibromatosis type 1 (NF1) is the onset of dermal or plexiform neurofibromas, mainly composed of Schwann cells. Plexiform neurofibromas can transform into malignant peripheral nerve sheath tumors (MPNST) that are resistant to therapies. EXPERIMENTAL DESIGN The aim of this study was to identify an additional pathway in the NF1 tumorigenesis. We focused our work on W...