نتایج جستجو برای: pleiotropic effects

تعداد نتایج: 1549019  

Journal: :Journal of Neuropathology & Experimental Neurology 2003

Journal: :Journal of lipid research 2008
Amanda Vinson Michael C Mahaney Vince P Diego Laura A Cox Jeffrey Rogers John L VandeBerg David L Rainwater

Both lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity, a biomarker of inflammation, and concentration of its primary associated lipoprotein, LDL, are correlated with adverse coronary outcomes. We previously reported a quantitative trait locus (QTL) corresponding to HSA2p24.3-p23.2 with pleiotropic effects on Lp-PLA(2) activity and LDL-cholesterol (LDL-C) concentration in baboons f...

2015
Symen Ligthart Paul S. de Vries André G. Uitterlinden Albert Hofman Oscar H. Franco Daniel I. Chasman Abbas Dehghan

Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic background of inflammation and cardiometabolic phenotypes using published genome-wide association stu...

Journal: :Current opinion in anaesthesiology 2006
Martin Dunkelgrun Olaf Schouten Harm Hh Feringa Radosav Vidakovic Don Poldermans

PURPOSE OF REVIEW This review evaluates clinical and experimental articles that have recently been published on the cardioprotective effect of perioperative statin therapy. RECENT FINDINGS Perioperative statin therapy improves short and long-term cardiac outcome following noncardiac surgery. This cardiovascular protection has been attributed to the so-called pleiotropic effects, which have a ...

2015
Anping Cai Yingling Zhou Liwen Li

3 A (HMG-CoA) reductase inhibitors or statins are a class of medications with potent effects on reducing serum cholesterol level, and currently have been widely used in the primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVD). Previously, a substantial number of clinical studies consistently demonstrated that through decreasing serum cholesterol level, especially ...

2015
Anping Cai

3 A (HMG-CoA) reductase inhibitors or statins are a class of medications with potent effects on reducing serum cholesterol level, and currently have been widely used in the primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVD). Previously, a substantial number of clinical studies consistently demonstrated that through decreasing serum cholesterol level, especially ...

Journal: :Applied and Environmental Microbiology 2019

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