Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated.THE NEW COMPLEXES ARE: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and (1)H and (13)C NMR spectra.They were tested agains...

Two Palladium complexes are presented as a promising alternative to platinum drugs disadvantages, controlling the speciation and limiting toxicity. Their interaction vs. biological targets their efficiency demonstrated, being more specific than benchmark cisplatin drug.

Six novel platinum(II) complexes 1-6 bearing different furoxan moieties as nitric oxide (NO) donors have been designed, synthesized, and characterized by elemental analysis and (1)H NMR, IR, and ESI-MS spectroscopy. The furoxan groups were introduced to the platinum complexes to release NO, which may take synergic action with the platinum-based moieties on the tumor cells. It was found that all...

The dicarbene platinum complexes of the type [Pt(L)2]Br2 [5]Br2 – [8]Br2 (L = N-alkyl-N′picolylbenzimidazolin-2-ylidene) have been prepared by two different methods. The in situ deprotonation of picoline-functionalized benzimidazolium salts 1 – 4 with platinum acetylacetonate gave the platinum complexes [5]Br2 – [8]Br2 in good yields. Complex [8]Br2 has also been obtained by a ligand transfer r...

A series of mono- and dinuclear alkynylplatinum(II) terpyridine complexes containing the hydrophilic oligo(para-phenylene ethynylene) with two 3,6,9-trioxadec-1-yloxy chains was designed and synthesized. The mononuclear alkynylplatinum(II) terpyridine complex was found to display a very strong tendency toward the formation of supramolecular structures. Interestingly, additional end-capping with...

BACKGROUND In our previous study we reported the synthesis and cytotoxicity of two trans-platinum(II) complexes: trans-[PtCl2(3-acetylpyridine)2] (1) and trans-[PtCl2(4-acetylpyridine)2] (2), revealing significant cytotoxic potential of 2. In order to evaluate the mechanism underlying biological activity of both trans-Pt(II) isomers, comparative studies versus cisplatin were performed in HeLa, ...

In this report we discuss the development of blue OLEDs employing tetradentate platinum complexes, which demonstrated a OLED with an external quantum efficiency 17.6% and estimated LT90 lifetime close to 600h at 1000 nits.

The binding modes of some non-platinum metal anticancer complexes, Cp(2)TiCl(2), Cp(2)ZrCl(2), (CH(3))(2)SnCl(2), (C(2)H(5))(2)SnCl(2), (C(2)H(5))(2)SnCl(2)(phen) (phen=Phenanthroline) and cis-Ru(II)Cl(2)(DMSO)(3) (DMSO) (cis-RDT) with nucleotides and DNA in aqueous solution at physiological pH values were investigated by various modern techniques. 5'-dGMP with Cp(2)TiCl(2) or cis-RDT forms che...

The bis-sulfoxide ligand p-tolyl-binaso and its derivatives can be used to synthesize neutral and cationic palladium and platinum complexes. Various Pt bis-sulfoxide complexes could be made by using the precursor Pt(M,SS,SS)-p-tolyl-binasoCl2 (5a) and abstracting the chlorides with silver salts. The Pd analogue of this compound (4) could not be used in the same way. In this case, the sulfoxides...