PURPOSE To systematically review the current evidence for the effects of platelet concentrates on (1) graft maturation and (2) graft-bone interface healing in anterior cruciate ligament (ACL) reconstruction in human, controlled trials and for ensuing differences in clinical outcomes. METHODS A systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Emba...

background: the purpose of the present in vitro study was to evaluate the effect of long term storage of conventional platelet concentrates (pcs) on major platelet receptors cd42b and cd41/cd61 by flow cytometry method and also measuring the overall platelet procoagulant activity status using platelet factor 3 (pf3) assay. materials and methods: six random units of conventional platelet concent...

Background: Recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. We aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. Methods: In vitro susceptibility to samples of 10 random human platelet concentrates was determin...

BACKGROUND The Mirasol Pathogen Reduction Technology system for platelets and plasma uses riboflavin and UV light to introduce irreparable lesions into nucleic acids thereby inhibiting pathogen and white blood cell replication and reducing the load of infectious pathogens. The aim of the present study was to evaluate low plasma buffy coat platelet concentrates obtained from the OrbiSac System a...

Platelet concentrates should be quality-assured of purity and identity prior to clinical use. Unlike for the liquid form of platelet-rich plasma, platelet counts cannot be directly determined in solid fibrin clots and are instead calculated by subtracting the counts in other liquid or semi-clotted fractions from those in whole blood samples. Having long suspected the validity of this method, we...

Platelet concentrates for surgical use are tools of regenerative medicine designed for the local release of platelet growth factors into a surgical or wounded site, in order to stimulate tissue healing or regeneration. Leukocyte content and fibrin architecture are 2 key characteristics of all platelet concentrates and allow to classify these technologies in 4 families, but very little is known ...