The importance of plasminogen activation, mediated by urokinase (uPA) and its receptor (uPAR), is well established in many physiologica and pathological processes, such as in cell migration and tumor-cell invasion. Recently, additional functions have been described for uPA and uPAR, particularly in cell adhesion and chemotaxis. The amounts of uPA and uPAR in various tumor types and in the plasm...

The importance of plasminogen activation, mediated by urokinase (uPA) and its receptor (uPAR), is well established in many physiological and pathological processes, such as in cell migration and tumor-cell invasion. Recently, additional functions have been described for uPA and uPAR, particularly in cell adhesion and chemotaxis. The amounts of uPA and uPAR in various tumor types and in the plas...

By CHARLES A. HALL With the technical assistance of Alexander E. Finkler, Edward S. Allen and Booker T. Moore T HE PLASMA vitamin B12 is abnormally high in chronic myelocytic leukemia.’8 It is sometimes increased above normal in polycythemia vera35 and myeloid metaplasia,35 but usually not as strikingly so. The plasma vitamin B12 is normal in chronic lymphocytic leukemia,12’4’5’8 lymphoma,4’5’8...

L-selectin is expressed by most leukocytes and mediates the initial step of adhesion to vascular endothelium. A feature of this adhesion receptor is to be shed from the cell surface. We report here the presence of high levels of the shed form of L-selectin (sL-selectin) in plasma from patients with acute leukemia. We also show that sL-selectin purified from acute leukemia plasma exhibits functi...

introduction: hcl is a rare malignant condition that is curable if diagnosed early. hcl can present with reduced blood cells and splenomegaly which maybe misdiagnosed with other conditions. the aim of the present study was to determine the frequency of early clinical and laboratory findings as well as the response rate of patients to the standard treatment regimen of cladribine. methods: the st...

By M. C. BLANCHAER, P. T. GREEN, J. P. MACLEAN AND M. J. HOLLENBERG W IDE ACCEPTANCE of serum glutamic oxaloacetic transaminase estimations1 for the detection of myocardial infarction has stimulated interest in the possible diagnostic uses of other plasma enzymes, including lactic acid dehydrogenase ( LD ) and phosphohexose isomerase ( PHI ) . Both of these enzymes play a role in the intracellu...

Intracellular lysozyme (muramidase) activity was measured in leukemic blasts and mature neutrophilic granulocytes from 20 patients with acute myeloblastic and myelomonocytic leukemia and in 11 patients with acute lymphoblastic leukemia after differential centrifugation of cells in Ficoll and extraction of lysozyme with n-butanol. Considerable abnormalities in cellular lysozyme activity were fou...