Background Microbiota-derived short chain fatty acids (SCFA) and liposaccharide (LPS) could modulate astrocyte neuronal activity. Glial fibrillary acidic protein (GFAP) neurofilament light (NfL) are markers of astroglial activation damage, can be measured in blood samples have been associated with Alzheimer’s disease (AD) pathology. The aim the present study was to assess association SCFAs LPS ...

Pharmacokinetics Modeling Q. Wang, Y. Zhang, S. Peng, Q. Zhang, C-H. Wong, H. E. Chan, Z. Zuo Chinese University of Hong Kong Purpose Intranasal administration (IN) has been a popular route for target delivery to the central nervous system (CNS) due to its potential to bypass the blood-brain barrier (BBB). However, there are limited studies and controversial evidence on the direct transport of ...

Hypophosphataemia is known to induce reversible myocardial dysfunction, but the incidence of hypophosphataemia and its effect on myocardial function during brain death are unknown. In 90 consecutive brain-dead patients, we measured plasma concentrations of phosphate and left ventricular ejection fraction area (LVEFa), using transoesophageal echocardiography. In 15 severely hypophosphataemic (< ...

Journal of Psychiatry & Neuroscience 293 The α-methyl-L-tryptophan (α-MTrp) method for the study of the brain serotonergic system is based on the fact that labelled α-MTrp is taken up by and, in part, retained in the brain, and this retention (trapping) is proportional to brain serotonin (5-HT) synthesis. A 3-compartment model is proposed in which the plasma, the precursor and irreversible pool...

abetalipoproteinemia (abl) is a very rare autosomal recessive disorder caused by mutations in the microsomal triglyceride transfer protein gene (mttp). abl is characterized by lack of lipids and apolipoprotein b (apob) in plasma, fat malabsorption and various clinical manifestations. we describe a 12-month-old infant boy, born from consanguineous parents and presented with diarrhea, steatorrhea...

Spectrin is a major cytoskeletal component of the brain. At least 2 distinct spectrin subtypes are found in mammalian brain: brain spectrin(240/235) and brain spectrin(240/235E). In the present study spectrin subtypes were localized in the adult mouse brain by immunoelectron microscopy using antibodies that recognize each subtype. Brain spectrin(240/235E) was concentrated in neuronal cell bodie...

Background: The blood-brain barrier (BBB) is a major hurdle to successful pharmacotherapy of brain tumors. ABCB1 and ABCG2 are efflux transporters that expressed in tumor vessels reduce the uptake many small molecule drugs. Elacridar tariquidar both dual inhibitors. We aim improve cancer by concomitant use potentially effective drugs with elacridar. Since has mostly been used assess effects ABC...

Cystic formation in human primary brain tumors is a relatively rare event whose incidence varies widely according to the histotype of tumor. Composition cystic fluid has mostly been characterized samples collected at time tumor resection and no indications evolution content are available. We proteome using bottom-up proteomic approach on sequential obtained from secretory meningioma (SM), schwa...

The gastrointestinal system may be involved in the etiopathogenesis of insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy activation GLP-1 receptors (GLP-1R) exerts neuroprotection controls peripheral metabolism. Intracerebroventricular administration streptozotocin (STZ-icv) used t...

The presence in brain of kynurenine, the first major metabolite of tryptophan on the pathway initiated by the liver enzyme. tryptophan pyrrolase, has recently been reported Since an enzyme capable of forming kynur-enine from tryptophan is present in brain (Gal, 1974; Hayaishi, 1976) it is of interest to study the penetration of kynurenine to the brain following peripheral administration. Periph...