he recent wave of enthusiasm for including inflammation s one of the primary pathophysiologic processes in cardioascular disease has substantial merit (1). Arterial inflamation is central to plaque progression and plaque rupture. mong clinical markers of inflammation, C-reactive protein CRP), a complex pentameric protein largely of hepatic rigin, is the current gold standard (2,3). In a variety...

Oral disease an on-going concern During the last century, there has been a world-wide surge of interest in veterinary dentistry. Interstitial gingivitis or so-called pyorrhoea alveolaris” was reported in dogs as far back as 1899. In 1939 the prevalence of dental disease and requirement for surgical intervention in dogs was also reported. Dental disease is certainly not a new “modern” problem in...

BACKGROUND Goal of this in vivo prospective, randomized, controlled, double-blinded, cross over study was to compare the level of plaque control and gingivitis after use of a novel dental gel (test) vs. A Triclosan/copolymer dentifrice (control). METHODS After coronal polishing, 22 subjects with moderate gingivitis were randomly assigned to brush twice daily with test or control dentifrice fo...

BACKGROUND AND PURPOSE The risk for cardiovascular events is related to the composition and stability of an atherosclerotic plaque driven by inflammation and deposition of lipids. Scavenger receptors are a family of cell surface receptors involved in lipid uptake and inflammation. Recently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with in...

Gingival recession is commonly associated with plaque-induced inflammation and calculus. A high frenal attachment is more important in gingival recession in the child-patient. A healthy child-patient with impeccable oral hygiene presented with localized gingival recession without plaque-induced inflammation which led to the exploration of other possible etiologies. Multiple factors appeared to ...

In 1856, Rudolf Virchow proposed that the atherosclerosis was caused when plasma components (including lipids) elicited an inflammatory response in the arterial wall. Current research also points that inflammation plays a central role in genesis of atherosclerosis and its complications. In early atherosclerotic lesions, immune cells dominate and their effector cells leads to progression of athe...

Restorative dentistry and periodontal health are closly related. Changes which occur in the periodontal tissues during and after restorative treatments of dental caries can be expected not only on theo retical grounds but also can be observed in the daily routine practice. Various experiments have been made concerning the character of these changes. A series of animal experiments concerning the...

BACKGROUND AND PURPOSE Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to separate asymptomatic plaques from those responsible for recent cerebrovascula...