نتایج جستجو برای: plant protease inhibitors
تعداد نتایج: 610431 فیلتر نتایج به سال:
The SARS-CoV-2 main protease (Mpro) has been chosen as a conserved molecular target to develop broad-spectrum antiviral drugs. Using docking and dynamics (MD) simulations, total of 5600 natural compounds available for virtual screening were tested identify potential inhibitors Mpro. As result, three (pentagalloylglucose, malonylawobanin gnetin E dihydride) found be SARS-CoV-2, which confirms th...
The plant apoplast is a harsh environment in which hydrolytic enzymes, especially proteases, accumulate during pathogen infection. However, the defense functions of most apoplastic proteases remain largely elusive. We show here that newly identified small cysteine-rich secreted protein PC2 from potato late blight Phytophthora infestans induces immunity Solanum plants only after cleavage by subt...
First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths, especially of patients with advanced liver disease. We aimed to assess whether first generation protease inhibitors interfere with neutrophil f...
The serine proteinase inhibitor from barley seeds, chymotrypsin inhibitor 2(CI-2), has been crystallized in a molecular complex with subtilisin Novo (EC 3.4.21.14). The crystal structure of this complex has been determined at 2.1-A resolution by the molecular replacement method and partially refined by restrained-parameter least-squares methods. The present crystallographic R factor (SigmaFo[un...
The amino acid sequence of the major trypsin inhibitor, F, of ungerminated mung beans (Vigna radiata [L.] Wilczek) was determined by a combination of automatic solid phase and manual sequencing techniques. F is a typical Bowman-Birk-type proteinase inhibitor with 80 amino acid residues and exhibits a high degree of identity with the other sequenced members of the Bowman-Birk family of inhibitor...
There are evidences indicating that cysteine proteases play an essential role in malaria parasites; therefore, an obvious area of investigation is the inhibition of these enzymes to treat malaria. Small cysteine protease inhibitors of malaria are well studied, but macromolecular nature of inhibitor is a new field to explore. In malarial cysteine proteases, there are macromolecular endogenous in...
BACKGROUND The HIV protease is essential for the life cycle of the virus and is an important target for the development of therapeutic treatments against AIDS. The structures of HIV protease in complex with different inhibitors have helped in understanding the interactions between inhibitors and the protease and in the design and optimization of HIV protease inhibitors. RESULTS We report here...
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