Background: We aimed to compare the efficacy of local injection therapies for lateral epicondylitis in a Bayesian framework. Methods: We searched the Embase, PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and ProQuest, for randomized controlled trials published from inception to February 2021 in any languages. The injection therapies included corticosteroids (C...

Purpose: To assess the efficacy and safety of single-dose, intra-articular (IA) administration UBX0101 in patients with painful knee osteoarthritis (OA). is a p53/MDM2 interaction inhibitor that can induce apoptosis senescent synoviocytes. Results from recent Phase 1 study (NCT03513016) suggested IA had dose-dependent, clinically meaningful effects on pain function OA. Methods: This was 2, rand...

Background Guidelines suggest glucocorticoids (GC) should be used as bridge therapy in rheumatoid arthritis (RA), but many patients are treated chronically with low doses. The effects of withdrawal such has not been studied extensively. Objectives To study disease activity score (DAS28), flares and signs adrenal insufficiency after blinded trial medication (prednisolone 5 mg/day or placebo for ...

griseofulvin is a well-known, effective, systemic antifungal agent which has not been used topically in the current clinical practice. in order to treat the common superficial fungal infection of tinea versicolor, a new topical formulation of griseofulvin (1%) was tried in 105 patients during a double blind study and its efficacy compared with placebo (its vehicle) and clotrimazol (1%) solution...

BackgroundSevere eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) remains the most relapsed subtype of uncontrolled CRSwNP. CM310, a humanised anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits IL-4 and IL-13 signaling which underlying inflammation. This study aims to evaluate efficacy safety CM310 in patients severe ECRSwNP.MethodsA multicentre, randomised, dou...

in the present study, the effect of intrauterine infusion of zataria multiflora extract on the clinical endometritis was investigated. vaginal examination, transrectal palpation and ultrasonography were used to inspect the genital tract at 30-40 days in milk and two weeks later the same approach was applied. cows with clinical endometritis were randomly divided into three treatment groups: z. m...

Background & AimsTreatments are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can reduce symptoms nausea and vomiting. We investigated the safety efficacy tradipitant, an antagonist NK1R, in patients with idiopathic or diabetic gastroparesis.MethodsWe performed a double-blind trial 152 adults gastroparesis at 47 sites United States from November 2016 t...

OBJECTIVE To evaluate the relative tissue concentrations of the endogenous vasoactive peptide endothelin 1 (ET-1) in random-pattern skin flaps (RPSF) treated with either topical anti-ischemic drug therapy (nifedipine) or placebo. DESIGN Prospective, randomized, placebo-controlled therapeutic trial. SUBJECTS Adult male Sprague-Dawley rats. INTERVENTION Experimental subjects underwent cauda...