Previous reports (1-9) have delegated a secondary role to anterior pituitary hormones in the control of aldosterone secretion.' Although hypophysectomy resulted in decreased aldosterone secretion (3) or reduced urinary aldosterone output (2), hyperaldosteronuria, marked sodium (Na) retention and ascites occurred in the absence of the adenohypophysis in dogs with thoracic inferior vena cava cons...

OBJECTIVE The effects of human leptin fragment(126-140) on pituitary function in eight healthy, non-obese men were studied. METHODS AND DESIGN The effects of the fragment on spontaneous secretion of pituitary hormones and endogenous leptin, as well as on GHRH-induced GH secretion were examined. RESULTS After the administration of the fragment (50 microg i.v. for 150 min), the mean nadir val...

The placenta of mammals is a very adaptable organ that accomplishes many critical functions necessary for the well-being of the host and developing fetus. For example, the placenta serves as an attachment site to secure the developing fetus to the uterus, and it transports nutrients from the maternal to the fetal compartment. During the evolution of viviparity, the placenta has assumed various ...

Purpose. The interaction of hormones of the pituitary-adrenal axis and adrenal cortex-associated circulating microRNAs is mostly unknown. We have studied the effects of dexamethasone and adrenocorticotropin on the expression of five circulating microRNAs (hsa-miR-27a, hsa-miR-200b, hsa-miR-214, hsa-miR-483-5p, and hsa-miR-503) reported to be related to the adrenal cortex in plasma samples. Meth...

Results are reported showing that pituitary extracts stimulate growth of 3T3 cells, an established line of mouse fibroblast. Cells were cultured in medium containing an organic buffer (HEPES; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid), which increases the serum requirement for cell growth. The pituitary growth-prompting activity is (a) not dialyzable; (b) thermolabile; (c) protease se...

Hepatic histidase activity in adult female rats is twice that in adult male rats. Hypophysectomy and thyroidectomy result in a significant increase in hepatic histidase activities in males, but not in females. This effect on histidase is reversed by the exogenous administration of tri-iodothyronine, but not by ectopic pituitary glands or purified pituitary hormones.

Hypothalamic-pituitary system represents a complex neuroendocrine unit that exerts its influence on the whole organism, by stimulating the target endocrine glands. In turn, the feedback of peripheral hormones strictly controls hypothalamicpituitary activity. In particular, the growth hormone-insulin-like growth factor I (GH-IGF-I axis) plays an important role in modulating other hypothalamic-pi...