Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. It has been reported anti-cancer, anti-amoebic, anti-mycobacterial, anti-mutagenic, anticonvulsant, anti-asthmatic, immunomodulatory, anti-inflammatory anti-oxidant activity. Therefore, the current investigation designed to unveil anticancer effects of piperine molecule against human ...

Abstract Background Black pepper [ Piper nigrum (L.), Family: Piperaceae] is used traditionally for the treatment of various diseases including; cough, cold, dyspnea throat diseases, intermittent fever, dysentery, stomachache, worms and piles. The pharmacological potential black due to presence metabolites like phenolic compounds, alkaloids, flavonoids, carotenoids, terpenoids, etc. multipurpos...

This study aimed to evaluate the antimicrobial and antibiofilm activities of black pepper essential oil (BPEO) piperine effect on gene expression in a multispecies biofilm composed Listeria monocytogenes, Salmonella Typhimurium, Pseudomonas aeruginosa polypropylene surface. The minimal inhibitory concentrations BPEO were 100 25 mg/mL, respectively, against this consortium microorganisms. Sessil...

British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society 1 BJCP-MP-00089-12-R1 Effect of an Herbal Extract Containing Curcumin and Piperine on Midazolam, Flurbiprofen, and Acetaminophen Pharmacokinetics in Healthy Volunteers Laurie P. Volak, Michael J. Hanley, Gina Masse, Suwagmani Hazarika, Jerold S. Harmatz, Vladimir Badmaev, Muhammed Majeed, David J. Greenblatt, an...

Piperine and capsaicin are important molecules with biological pharmacological activities. This study aimed to evaluate the cytogenotoxic protective effect of piperine on Allium cepa cells. A. roots were exposed negative (2% Dimethylsulfoxide) positive (Methylmethanesulfonate, MMS, 10 µg/mL) controls, four concentrations (25-200 µM) or (alone) associated before, simultaneously after MMS. Only l...

It was recently shown that in some subjects capsaicin can evoke bitterness as well as burning and stinging, particularly in the circumvallate (CV) region of the tongue. Because perception of bitterness from capsaicin is characterized by large individual differences, the main goal of the present study was to learn whether people who taste capsaicin as bitter also report bitterness from structura...

Piper nigrum is famous as the spices king due to its pungent quality[1]. Piper nigrum (P.nigrum) L. is a member of family Piperaceae[2-4]. The genus piper has more than 1000 species but the most well known species are P.nigrum, P.longum and P.betle; 51 cultivars of p. nigrum have been reported from the tropical and subtropical regions of India [5]. P.nigrum fruits are also used to produce white...