نتایج جستجو برای: piperazine citrate
تعداد نتایج: 17210 فیلتر نتایج به سال:
Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A [8] was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesize...
helminths infections are chronic illness in human being and cattle. the use of alternate drugs has been a remedial measure against the resistant strains of helminth parasites, as well as means of reducing the cost of controlling diseases caused by helminthes. pseudocedrelakotschyi is a medicinally valuable plant and possesses various pharmacological properties. p. kotschyi has been traditionall...
In the title compound, C(26)H(43)N(7)O, each piperazine ring adopts a chair conformation. Two 1-methyl-piperazine rings bond to one Csp(3) of the pyrrole ring via the piperazine N atoms, while the third one links to the N atom of the indolin-2-one unit through a flexible ethyl group with an almost syn conformation. In the crystal, mol-ecules are connected through methyl-ene-carbonyl C-H⋯O inter...
In the liver microsome cyanide (CN)-trapping assays, piperazinecontaining compounds formed significant N-methyl piperazine CN adducts. Two pathways for the N-methyl piperazine CN adduct formation were proposed: 1) The a-carbon in the N-methyl piperazine is oxidized to form a reactive iminium ion that can react with cyanide ion; 2) N-dealkylation occurs followed by condensation with formaldehyde...
Metabolites of a G protein-coupled receptor modulator containing 1,2,4-oxadiazole and piperazine substructures were identified in vitro in human, rat, and dog hepatocyte incubates and in vivo in rat plasma, bile, urine, and feces by using 14C-radiolabeled parent compound. Exposure coverage for the major circulating metabolites in humans at steady state and in preclinical species used in drug sa...
An amidase acting on (R,S)-piperazine-2-tert-butylcarboxamide was purified from Pseudomonas azotoformans IAM 1603 and characterized. The enzyme acted S-stereoselectively on (R,S)-piperazine-2-tert-butylcarboxamide to yield (S)-piperazine-2-carboxylic acid. N-terminal and internal amino acid sequences of the enzyme were determined. The gene encoding the S-stereoselective piperazine-2-tert-butylc...
The gelation properties of a zinc porphyrin bearing peripheral urea groups (1 x Zn) were evaluated in the absence and the presence of several diamines. In aromatic solvents such as benzene, toluene and p-xylene, 1 x Zn only provided the precipitate. In contrast, 1 x Zn with 0.5 and 1.0 equiv. of piperazine formed gels, and the gel with 0.5 equiv. of piperazine showed a unique physical property ...
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