Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a membrane protein that can support the binding, internalization, and proteolytic degradation of oxidized low-density lipoprotein. The LOX-1 expression increases in the neointima after balloon injury. To develop an efficient compound to inhibit LOX-1, we designed and synthesized a novel gene silencer pyrrole-imidazole (PI) polya...

Let p1, . . . , pn be positive real numbers. It is well known that for every r < 0 the matrix [(pi + pj) r ] is positive definite. Our main theorem gives a count of the number of positive and negative eigenvalues of this matrix when r > 0. Connections with some other matrices that arise in Loewner’s theory of operator monotone functions and in the theory of spline interpolation are discussed.

Introduction: There has been a rising interest in combining parallel imaging (PI) [1,2] with compressed sensing (CS) [3] to achieve high acceleration and reduce the noise amplification that comes from traditional PI reconstruction (e.g. SENSE[1], GRAPPA[2], etc). Existing approaches are: (a) sequentially apply PI and CS [4]; (b) sequentially apply CS and PI [5]; (c) simultaneously apply PI and ...

Integrin-linked kinase (ILK) is an ankyrin-repeat containing serine-threonine protein kinase capable of interacting with the cytoplasmic domains of integrin beta1, beta2, and beta3 subunits. Overexpression of ILK in epithelial cells disrupts cell-extracellular matrix as well as cell-cell interactions, suppresses suspension-induced apoptosis (also called Anoikis), and stimulates anchorage-indepe...

BACKGROUND Vascular calcification (VC) is prevalent in patients suffering from chronic kidney disease. Factors promoting calcification include abnormalities in mineral metabolism, particularly high phosphate levels. Inorganic phosphate (Pi) is a classical inducer of in vitro VC. Recently, an inverse relationship between serum magnesium concentrations and VC has been reported. The present study ...

Inflammatory cells are capable of degrading extracellular matrix macromolecules in vivo in the presence of proteinase inhibitors. We and others have hypothesized that such proteolysis is permitted in large part by mechanisms operative in the immediate pericellular environment, especially at zones of contact between inflammatory cells and insoluble matrix components. To further test this hypothe...

Abstract PAN-based carbon fiber was surface-modified with silane coating, and a composite material prepared using PI resin as matrix. The structure surface properties of fibers were studied by means X-ray photoelectron spectroscopy (XPS) SEM. tensile strength the measured tester, friction micro-nano mechanics comprehensive test system. results show that treatment coating can improve roughness c...

Members of the transforming growth factor (TGF)-beta family are important regulators of skeletal development. In this study, we investigated the effect of TGF-beta1 on inorganic phosphate (Pi) transport and on expression of the type III Pi carriers Glvr-1 and Ram-1 in murine ATDC5 chondrocytes. TGF-beta1 induced a selective, dose- and time-dependent increase in sodium-dependent Pi transport in ...