Valence topological charge-transfer (CT) indices are applied to the calculation of pH at the pI isoelectric point. The combination of CT indices allows the estimation of pI. The model is generalized for molecules with heteroatoms. The ability of the indices for the description of molecular charge distribution is established by comparing them with the pI of 21 amino acids. Linear correlation mod...

We examined the role of phosphatidylinositol 3-kinase (PI 3-K) in FMLP-stimulated cell-cell adhesion of human neutrophils. The specific PI 3-K inhibitors wortmannin and LY294002 inhibited neutrophil homotypic aggregation stimulated by chemoattractants such as FMLP (50% inhibitory concentration (IC50) approximately 11 nM and 13 microM, respectively) but not PMA. Wortmannin also inhibited FMLP-st...

We report the coherent coupling of two electron spins at a distance via virtual microwave photons. Each spin is trapped in silicon double quantum dot either end superconducting resonator, achieving spin-photon couplings up to around $g_s/2\pi = 40 \ \text{MHz}$. As are brought into resonance with each other, but detuned from photons, an avoided crossing larger than linewidths observed exchange ...

STUDY OBJECTIVES To examine the resting-state functional connectivity (FC) between subcortical regions in relation to whole-brain activity in patients with psychophysiological insomnia (PI) and changes following cognitive-behavioral therapy for insomnia (CBTi). METHODS The FC between subcortical seed regions (caudate, putamen, pallidum, amygdala, thalamus, and hippocampus) and whole-brain vox...

The ultrastructures of the pituitary pars intermedia of 11 male sheep about 1-13 months of age were observed. The following cells were distinguished in the sheep pars intermedia: pars intermedia glandular cells, marginal cells, interstitial cells, follicular cells, pars distalis-like granular cells, degenerating cells and mast cells. The pars intermedia glandular cells contain a well-developed ...

Activating mutations in the fibroblast growth factor 23 (FGF23) gene were identified as the cause of autosomal dominant hypophosphataemic rickets (ADHR) [1]. This secreted protein was later shown to play a role in both physiological and pathological phosphate handling. FGF23 may be the key pathogenetic molecule in three different diseases with hypophosphataemia and inappropriate regulation of v...

BACKGROUND AND PURPOSE To examine the neurophysiological basis for the pronounced differences in hyperactivity and impulsiveness that distinguish the predominantly inattentive type of attention-deficit/hyperactivity disorder (ADHD-PI) from the combined type of the disorder (ADHD-C). METHODS Event-related brain responses to a go/no-go test of inhibitory control were measured with functional ma...

INTRODUCTION In Denmark, it is compulsory to report post-operative infections (PI) to the Danish Health and Medicines Authority. The aims of the present study were to determine, firstly, the incidence of PI following elective ear, nose and throat (ENT) surgery as well as the number of cases reported to the Danish health authorities; secondly, the PI distribution in various surgical subgroups; a...

The membrane receptors for the gibbon ape leukemia retrovirus and the amphotropic murine retrovirus serve normal cellular functions as sodium-dependent phosphate transporters (Pit-1 and Pit-2, respectively). Our earlier studies established that activation of protein kinase C (PKC) by treatment of cells with phorbol 12-myristate 13-acetate (PMA) enhanced sodium-dependent phosphate (Na/Pi) uptake...

Posterino GS, Dunn SL. Comparison of the effects of inorganic phosphate on caffeine-induced Ca release in fastand slowtwitch mammalian skeletal muscle. Am J Physiol Cell Physiol 294: C97–C105, 2008. First published October 24, 2007; doi:10.1152/ajpcell.00155.2007.—We compared the effects of 50 mM Pi on caffeine-induced Ca release in mechanically skinned fast-twitch (FT) and slow-twitch (ST) ske...