Phthalates are a group of plasticizers that are widely used in many consumer products and medical devices, thus generating a huge burden to human health. Phthalates have been known to cause a number of developmental and reproductive disorders functioning as endocrine modulators. They are also involved in carcinogenesis with mechanisms less understood. To further understand the molecular mechani...

Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, we evaluated the levels of phthalates, non-phthalate plasticizers and bisphenols in dust from 100 Swedish preschools and identified important exposure factors in the indoor environment. In addition, children's total exposure to these chemicals was determined by urine analysi...

cern to Blount and co-workers (1) were the significantly higher concentrations of the dibutyl phthalate metabolite in the urine of childbearing-age women (20–40 years) than in that of other segments of the population. The presence of phthalate esters in polyvinyl chloride (PVC) toys has generated the most controversy. Regulators in Greece have completely banned soft PVC toys, and Austria, Denma...

The research is aimed at solving an urgent problem of microbiology, that studying bacterial degradation processes persistent environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs) and phthalates. study examined the ability bacteria Micrococcaceae family, isolated from technogenically polluted territories Perm Region, to degrade phthalates: esters ortho-phthalic acid, tereph...

Pure organic substances are the first and key link in chain of metrological traceability analysis. In most cases, purity determination substance is a non-trivial task, solution which requires preliminary theoretical study understanding capabilities instrumental methods for developing pertinent analytical procedure. Within study, an algorithm determining separate group compounds – ortho-phthalic...

BACKGROUND The EU 6th Framework Program (FP)-funded Health and Environment Network (HENVINET) aimed to support informed policy making by facilitating the availability of relevant knowledge on different environmental health issues. An approach was developed by which scientific agreement, disagreement, and knowledge gaps could be efficiently identified, and expert advice prepared in a way that is...

STUDY QUESTION Is there an association between exposure to phthalates and the timing of female puberty? SUMMARY ANSWER Our study suggests that the early onset of puberty is related to increased kisspeptin secretion. WHAT IS KNOWN ALREADY Girls are maturing earlier than in past decades and the quantity of phthalates used in consumer products has concurrently risen. The hypothesis that exposu...

Plasticizers known as phthalates are used in many medical and household products. They also are used in the coatings on timedrelease pharmaceuticals and dietary supplements, and high levels of phthalate metabolites have been found in subjects who take such products regularly. In a new study, investigators examined available data to determine the extent and scope of ortho-phthalate use in pharma...

BACKGROUND Phthalates are ubiquitous industrial chemicals used as plasticizers in plastics made of polyvinyl chloride (PVC) to confer flexibility and durability. They are also present in products used for personal-care, industry and in medical devices. Phthalates have been associated with several adverse health effects, and recently it has been proposed that exposure to phthalates, could have a...

A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalat...