Corticosterone (CORT)-induced oxidative stress and neurotoxicity can cause neuronal dysfunction mental disorders. In the present study, we investigated effects mechanism of HP-20 resin fraction water extract Vaccinium bracteatum leaves (NET-D1602) its bioactive compound p-coumaric acid on cell damage in SH-SY5Y cells primary culture rat cortical cells. NET-D1602 significantly improved viability...

The RNA binding protein YBX1 is a key regulator of epidermal progenitor cell senescence that prevents the mRNA translation critical senescence-associated secretory phenotypes (SASP) transcripts such as CXCL1 and IL8. Decreased levels during aging enables production SASP-related proteins subsequent induction senescence. Posttranslational modifications YBX1, phosphorylation at Ser 102, can modify...

Glioblastoma (GBM) is the most frequent and aggressive primary malignant brain tumor PI3K/Akt signaling pathway activated in almost 90% of cases. The aim this study was to evaluate capacity natural compounds potentiate activity temozolomide (TMZ) - standard pharmacological drug for GBM. U-87 MG (ATCC HTB-14) cells were treated with quercetin, resveratrol, curcumin TMZ, alone or combination TMZ ...

Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC 20 ) is a critical switch leading to SM contraction. The canonical view held that only the short isoform kinase (MLCK1) catalyzed this reaction. It now accepted auxiliary kinases may contribute vascular tone and contractility. We have previously reported p90 ribosomal S6 (RSK2) functions as such kinase, in pa...