5-(p-Substituted phenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amines 10-17 were prepared utilizing different p-substituted benzoic acid through two step reactions. Firstly, thiosemicarbzide was reacted with benzoic acid derivatives 1 in the presence of phosphorus oxychloride to give 2amino-5-substituted-1,3,4-thiadiazoles 2-9. These compounds were reacted with 5-nitro-2-furanacr...

A simple and efficient synthesis of dioxazaphosphinin-2-ones has been developed by the cyclisation of 2-hydroxy-1,2-diphenylethanoneoxime with phosphorus oxychloride in the presence of triethylamine in dry THF to afford the corresponding monochloride. In the next step, subsequent reaction of monochloride with different amines at 50-60 ̊C for 2-3 hours resulted in the formation of the title comp...

Escherichia coli alkaline phosphatase (AP) can hydrolyze a variety of chemically diverse phosphate monoesters while making contacts solely to the transferred phosphoryl group and its incoming and outgoing atoms. Strong interactions between AP and the transferred phosphoryl group are not present in the ground state despite the apparent similarity of the phosphoryl group in the ground and transit...

In the mol-ecular structure of the title compound, [CaNa(C10H20Cl3N3O2P)3(H2O)], the Ca2+ ion has a slightly distorted octa-hedral coordination environment defined by six O atoms which belong to the carbonyl and phosphoryl groups of the three coordinating ligands. Two Cl atoms of CCl3 groups and four O atoms form the coordination environment of the Na+ ion: three from the carbonyl groups of lig...

In the course of synthesizing a number of aryl phosphate esters as substrates for prostatic acid phosphatase, polymeric phosphorylated products obtained by reaction of 4,4’-dihydroxybiphenyl with phosphorus oxychloride were found to be potent enzyme inhibitors. This report describes the preparation of these anionic polymers and some characteristics of their inhibition of prostatic acid phosphat...

A series of phosphoglycerides containing the same structural unit, 1-O-alkyl-2-acetyl-sn-glycerol, was prepared with the following polar head groups: -3-phosphoric acid (AGEPA), -3-phosphorylethanol (AGEPEt), -3-phosphorylethanolamine (AGEPE), -3-phosphoryl-N-monomethylethanolamine (AGEPMME), -3-phosphoryl-N,N-dimethylethanolamine (AGEPDME), and -3-phosphorylcholine (AGEPC). These compounds wer...

ortho-Lithiation of cyclic aryl sulfonamides in the presence of phosphoryl chloride provides a very simple entry to fused polycyclic sultams (benzothiazolines and naphthathiazolines).