A Stability indicating reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Levocetirizine dihydrochloride and Pseudoephedrine sulfate in pharmaceutical formulation. The mobile phase A consisted of Potassium dihydrogen phosphate Buffer 0.05M and 1-Ocatne sulphonic acid sodium salt 0.25%, pH adjusted to 3.0 with orthophospheric aci...

This study concerns the fast and accurate solution of the line radiation transfer problem, under non-LTE conditions. We propose and evaluate an alternative iterative scheme to the classical ALI-Jacobi method, and to the more recently proposed Gauss-Seidel and Successive Over-Relaxation (GS/SOR) schemes. Our study is indeed based on the application of a preconditioned bi-conjugate gradient metho...

A reverse phase highperformance liquid chromatographic (RP-HPLC) method in gradient mode has been developed and evaluated for its ability to simultaneously establish the level of known impurities as well as the unknown impurities in pioglitazone and glimepiride tablets. The best separation was achieved on Eclipse XDB-C8, 5m, 4.6  150mm column. Use of 0.1N sodium dihydrogen phosphate dihydrate...

Using an extension of some previously proposed modified secant equations in the Dai–Liao approach, a modified nonlinear conjugate gradient method is proposed. As interesting features, the method employs the objective function values in addition to the gradient information and satisfies the sufficient descent property with proper choices for its parameter. Global convergence of the method is est...

A stability-indicating high-performance liquid chromatographic (HPLC) method was developed with short run time and validated for the assay of process related impurities of pantoprazole in bulk form. Resolution of drug, its potential impurities and degradation products were achieved on a Hypersil ODS column utilizing a gradient with 0.01 M phosphate buffer of pH 7 and acetonitrile as eluent, at ...

A simple, robust, and stability-indicating reversed-phase high-performance liquid chromatographic (HPLC) method for the analysis of apixaban and its related substances has been successfully developed. Chromatography was performed on a 250 mm × 4.6 mm, 5 μm C18 column with a gradient mixture of a phosphate buffer-methanol 60:40 (v/v) at 1.0 mL min(-1). Ultraviolet detection of apixaban was at 22...

Numerical identification of diffusion parameters in a nonlinear convection–diffusion equation is studied. This partial differential equation arises as the saturation equation in the fractional flow formulation of the two–phase porous media flow equations. The forward problem is discretized with the finite difference method, and the identification problem is formulated as a constrained minimizat...