The glmS riboswitch is unique among gene-regulating riboswitches and catalytic RNAs. This is because its own metabolite, glucosamine-6-phosphate (GlcN6P), binds to the riboswitch and catalytically participates in the RNA self-cleavage reaction, thereby providing a novel negative feedback mechanism. Given that a number of pathogens harbor the glmS riboswitch, artificial actuators of this potenti...

      This study presents the influence of hydroxypropyl-β-cyclodextrin (HPBCD) on the aqueous solubility of acyl esters of cyproterone. First, a number of esters of cyproterone were synthesized. Then the phase solubility analysis of the compounds in the presence of HPBCD was investigated in phosphate buffer solution at a pH of 7.4. To gain a better understanding of the complexation mechanism, ...

THE fact that phosphates stimulate the respiratory sugar metabolism in higher plants suggests that the formation of phosphoric esters may occur as part of this process. Stoklasa et al. [1904-1913] obtained cell-free zymase-like preparations from peas, beet-roots, potatoes etc., which actively fermented sugars. Bodnar [1916] confirmed these results under strictly aseptic conditions, since some i...

IN a previous communication [Kendal & Stickland, 1937, 1] it was shown that if rabbit muscle is minced and thoroughly washed with water, and then extracted several times with dilute Na2HPO4, the later extracts (usually the 4th) contain much of the glycolytic enzyme system but are freer from coenzymes than extracts prepared by earlier methods. This was shown by the fact that on addition of boile...

Objective. Succnic acid mono ethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and Metformin on the activities of carbohydrate metabolic enzymes in streptozotocinnicotinamide induced type 2 diabeteic model was investigated. Methods. EMS were injected intraperitonially at doses 2...

In an investigation to determine whether phosphorylated intermediates are concerned in tumor glycolysis a series of analyses was carried out for the esters and related components of the EmbdenMeyerhof glycolysis scheme (3). The methods used were dependent upon specific properties of these metabolites, shown to be dependable for analyses in certain differentiated tissues by isolations and experi...

To understand the role of phosphate ester dispersant, we investigated rheology a BaTiO slurry. For model case, coarse-grain molecular dynamics (CGMD) simulation was performed with butyral polymer didodecyl hydrogen (DHP) in toluene/ethanol solvent. By systematically analyzing effect DHP from an atomic-scale first principle and all-atom MD to microscale CGMD simulation, how adsorption dispersant...