The Src homology 2 containing inositol 5-phosphatase (SHIP2) is a large multidomain enzyme that catalyzes the dephosphorylation of phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2. PI(3,4,5)P3 key lipid second messenger controlling recruitment signaling proteins plasma membrane, thereby regulating plethora cellular events, including proliferation, growth, apo...

Cancer cells often depend on microenvironment signals from molecules such as cytokines for proliferation and metabolic adaptations. PRL-3, a cytokine-induced oncogenic phosphatase, is highly expressed in multiple myeloma associated with poor outcome this cancer. We studied whether PRL-3 influences metabolism. Cells transduced to express had higher aerobic glycolytic rate, oxidative phosphorylat...

Two members of a placental alkaline phosphatase (PLAP) family, PLAP and PLAP-like or germ cell alkaline phosphatase, are aberrantly expressed in tumors of ecotropic origin. To characterize alkaline phosphatase induced in seminoma, alkaline phosphatase cDNA clones were isolated from a cDNA library constructed from seminoma cells and characterized by nucleotide sequence determination. Thus, isola...

Red cell phosphoglycolate phosphatase (PGP) and 2,3-diphosphoglycerate (2,3-DPG) were investigated in normal and anemic patients and rabbits. In hemolytic anemia and blood-loss anemia, characterized by a young red cell population, there was an increase in both phosphoglycolate phosphatase activity and 2,3-diphosphoglycerate levels. In aplastic anemia, the phosphoglycolate phosphatase activity w...

Protein Phosphatase 6 down-regulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits psoriasis, indicating restoration of protein phosphatase can be rational strategy for psoriasis treatment. Through phenotypic screen, we here identify L-menthol ameliorates psoriasis-like skin inflammation by increasing keratinocytes. Target identification approaches reveal an indi...

1. Four diabetogenic ureides were examined for their power to inhibit alkaline phosphatase and were all highly active. Of ten related compounds examined, two were poor inhibitors of phosphatase although not diabetogenic and non-inhibiting for phosphatase. The anti-phosphatase activity seems to reside in a free 5-hydroxyl group. 2. This action on phosphatase has been demonstrated in the presence...