Abstract Introduction Hypersomnia sleep disorders are characterized by overwhelming daytime sleepiness. Treatment options include sodium oxybate the salt of γ-hydroxybutyric acid (GHB). Oxybate, an endogenous metabolite GABA, acts through GABAB noradrenergic and dopaminergic neurons, as well at thalamocortical neurons. < 1% may experience suicidal ideations or psychosis. Report case(s) A...

Background: The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that may also be affected by genetically influenced hyperhomocysteinaemia. To determine whether the C677...

OBJECTIVE To evaluate the efficacy and tolerability of frovatriptan in acute migraine treatment. METHODS Systematic review and meta-analysis of randomized controlled trials. Clinical trials of frovatriptan were systematically identified through electronic searches and historical searches up until February 2005. Studies were included if they were (i) double-blind, randomized, placebo controlle...

Headache is an almost ubiquitous human experience. In addition, it is a major contemporary health problem about which most clinicians are poorly informed. Over two-thirds of the population report a history of headache, with 28% fulfilling criteria for a diagnosis of migraine and 38% for tension-type headache.' Patients come to medical attention either because of diagnostic doubt (is it a brain ...

BACKGROUND Migraine is characterized by headache with symptoms such as intense pain, nausea, vomiting, photophobia, and phonophobia that significantly impact individuals' lives. The objective of this study was to develop a strategy to measure outcomes from the patients' perspectives for use in evaluating preventive treatments for migraine. METHODS This study used a multi-stage process. The fi...

EDITORIAL Bilateral paroxysmal hemicrania or bilateral paroxysmal cephalalgia, another novel indomethacin-responsive primary headache syndrome? Bingel and Weiller (1) report a case of short-lasting, frequent, bilateral, indomethacin-responsive headache without cranial autonomic features in this issue of Cephalalgia. They consider this to be a bilateral form of paroxysmal hemicrania (PH). We not...

" What do cortical thickness increases mean and what are the potential implications? " Migraine is a very widespread and debili-tating disease and according to the WHO, one of the most common disorders of the nervous system. Prevalence studies estimate that migraine affects 15–25% of women and 6–8% of men [1–4], and over 2.5 million people in North America have migraine at least one day per wee...

CASE PRESENTATION History of Present Illness:The patient is a 32-yearold physician with seasonal allergies, depression, and hypothyroidism who presented to the resident neurology clinic for treatment of headaches. At the time of her visit she had a headache.She states that she had her first headache at approximately 5 to 10 years of age.At that time she would get a headache“when the weather was...

IMPORTANCE Migraine is a common disorder and a frequent cause of medical consultation in children. Many childhood episodic syndromes have been described as common precursors of migraine. OBJECTIVE To review current knowledge on migraine and childhood episodic syndromes, and to discuss future directions for research and clinical practice. FINDINGS For most children it is difficult to describ...

BACKGROUND Exploring clinical characteristics and migraine covariates may be useful in the diagnosis of migraine without aura. OBJECTIVE To evaluate the diagnostic value of the International Classification of Headache Disorders (ICHD)-III beta-based diagnosis of migraine without aura; to explore the covariates of possible migraine without aura using an analysis of grey zones in this area; and...