The anticonvulsant activity of Astragalus squarrosus total extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice, with diazepam as the standard drug, while mechanistic studies were also conducted using flumazenil, a GABA A-benzodiazepine receptor complex site antagonist. The extract produced protection against convulsion at 400 mg/kg, comparable with protection of benzodia...

Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S-17177 Stockholm, Sweden Laboratory for Neural Microcircuitry, Brain Mind Institute, EPFL, Lausanne CH-1015, Switzerland Laboratory of Theoretical Neurobiology, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium School of Neurology, Neurobiology and Psychiatry, Univer...

A new natural product named trolliamide was isolated from Trollius chinensis Bunge. Its structure was determined as 2-hydroxy-tetracosanoic acid(2,3-dihydroxy-1-hydroxymethyl-heptadec-7-enyl)-amide by spectroscopic methods, including UV, IR, MS and NMR. This is the first report of a ceramide isolated from Trollius chinensis.

́ 1 1 ISIDORO GARCIA]CRUZ, M. E. RUIZ]SANTOYO ́ 2 3 J. RAUL ALVAREZ]IDABOY, ANNIK VIVIER]BUNGE 1 Gerencia de Ciencias del Ambiente, Instituto Mexicano del Petroleo, 07730 Mexico, D.F., Mexico ́ ́ ́ 2 Laboratorio de Quımica Computacional y Teorica, Facultad de Quımica, Universidad de La Habana, ́ ́ ́ Habana 10400, Cuba 3 Departamento de Quımica, Universidad Autonoma Metropolitana, Iztapalapa, 09340 Mexi...

Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component of Salvia miltiorrhiza Bunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti-inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis research, including immune cells, antigens,...