Some new mononuclear complexes [ML1L2(NO3)2 ] {where M = [Co(II), Ni(II), Cu(II) and Zn(II)], L1 = 2Hydroxy-5-nitrobenzaldehyde and L2 = diketones (Pentane-2,4-dione, 1-phenylbutane-1,3-dione, 1,3diphenylpropane-1,3-dione)}, have been synthesized and were characterized by elemental analysis, molar conductance, , FTIR spectra, UV, magnetic moment and thermo gravimetric analysis (TGA). The relati...

1H-Benzo[f]indazole-4,9-dione derivatives conjugated with C-protected amino acids (glycine, l-alanine, l-phenylalanine and l-glutamic acid) 6a-l were prepared by chemically modifying the prenyl substituent of 3-methyl-7-(4-methylpent-3-enyl)-1H-benzo[f]indazole-4,9-dione 2 through epoxidation, degradative oxidation, oxidation and N-acyl condensation reactions. The chemical structures of the syn...

Because of the importance of microbial metabolites of cholesterol as precursors in the synthesis of steroidal drugs, we decided to study the ability of Arthrobacter simplex to degrade cholesterol. Arthrobacter simplex cleaves the side chain of cholesterol in the presence of 2,2'-dipyridyl and produces 4-androstene-3,17- dione (AD) and androsta- 1,4-diene-3,17-dione(ADD). Two other intermedi...

BACKGROUND Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) has been designed as standard clinical terminology for annotating Electronic Health Records (EHRs). EHRs textual information is used to classify patients' diseases into an International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) category (usually by an expert). Improving the accuracy...

A one-pot three-component [2+3] cycloaddition for the synthesis of 1-alkyl 1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione and 2-alkyl 2H-naphtho[2,3-d][1,2,3]triazole-4,9-dione has been developed. By taking the advantage of difference in basicity, both products can be obtained in good purity. The unique heterocyclic scaffolds of these two products could exert interesting chemical and biological pro...

The Lewis acid-catalyzed domino 1,2-addition/1,4-addition/elimination between (Z)-3-hexene-2,5-dione and 1,3-dicarbonyls delivers 3-methyl-6,7-dihydrobenzofuran-4(5H)-ones exclusively with yields up to 82%. The combination of this new process with the laccase-catalyzed formation of (Z)-3-hexene-2,5-dione by oxidative cleavage of 2,5-dimethylfuran allows for the synthesis of 6,7-dihydrobenzofura...

Curcumin analogues are widely used in numerous biological disciplines. They employed the pharmaceutical sector and offer good pharmacology application prospects present era. In current study, two curcumin analogues—1,7-diphenylhepta-1,6-diene-3,5-dione (DPHDD) 1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione (BDMPHDD)—were tested vitro against bacterial strain S. aureus. The testing demons...

THE TITLE COMPOUND [SYSTEMATIC NAME: 2-(1H-1,2,3-benzotriazol-1-ylmeth-yl)isoindole-1,3-dione], C(15)H(10)N(4)O(2), was prepared by the reaction of 1H-benzotriazole and 2-bromo-methyl-isoindole-1,3-dione. The benzotriazole and isoindole units are almost planar and make a dihedral angle of 70.2 (1)° (mean planes include C and N atoms). A weak C-H⋯O intra-molecular hydrogen bond involving a carbo...

1,3-Dipolar cycloaddition of azomethine ylides derived from acenaphthylene-1,2-dione and 5methyl-benzo[b]-thiophene-2,3-dione with L-proline, thiazolidine-4-carboxylic acid and 1,2,3,4tetrahydroisoquinoline-3-carboxylic acid with various electron deficient dipolarophiles leads to the formation of novel spiroheterocycles having two or more chiral centers. Semiempirical studies have been performe...

A fast and convenient protocol for the synthesis of novel spiro[dihydropyridine-oxindole] derivatives in satisfactory yields was developed by the three-component reactions of arylamine, isatin and cyclopentane-1,3-dione in acetic acid at room temperature. On the other hand the condensation of isatin with two equivalents of cyclopentane-1,3-dione gave 3,3-bis(2-hydroxy-5-oxo-cyclopent-1-enyl)oxi...