Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding recognized as the main underlying pathogenic mechanism PKU. Therefore, use stabilizers protein structure and/or an attractive therapeutic strategy for this condition. Here, we report that 3-hydroxyqu...

Lifelong low-phenylalanine (Phe) dietary management is the foundation of care in phenylketonuria (PKU). However, strict monitoring of food intake places a burden on patients and their caregivers, and adherence to the required diet frequently decreases in later childhood and adolescence. Rarely, parents of children with PKU refuse to recognise the importance of treatment and follow-up for this c...

Abstract Dithiopyr and dinitroanilines are preemergence-applied, mitotic-inhibiting herbicides used to control goosegrass [ Eleusine indica (L.) Gaertn.] in turfgrass. A suspected resistant E. population was collected from a golf course putting green evaluated for possible resistance dithiopyr prodiamine. After dose–response evaluation, the α-tubulin gene sequenced known target-site mutations t...

Background: Growing evidence suggests a higher occurrence of overweight and obesity in children diagnosed with phenylketonuria (PKU), yet the exact cause is still unknown. Objectives: The objective to address prevalence PKU. Methods: In our cross-sectional study, we included 47 PKU who were receiving care at nutritional clinic National Nutrition Institute. We conducted anthropometric assessment...

Phenylalanine (Phe) is one of the amino acids that cannot be produced in body and must ingested through diet. Tyrosine (Tyr) also a non-essential acid can by Phe hydroxylation liver when dietary intake Tyr low. Structure analysis very important to know correct synthesis reactivity molecule. In this study, characterization molecules were investigated using quantum chemical calculations. The mole...

Blood phenylalanine (Phe) levels provide a practical and reliable method for the diagnosis and monitoring of metabolic status in patients with phenylketonuria (PKU). To assess the reliability of blood Phe levels as a predictive biomarker of clinical outcomes in the development of treatments for PKU, a systematic literature review and meta-analysis of published trials of PKU, which included Phe ...

This study focused on important characteristics of attentional (selective) processing in children with early-treated phenylketonuria (PKU). Seven to 14-year-old children with PKU were allocated to high phenylalanine (Phe) and low Phe groups and compared with control children on amplitudes and latencies of early and late event-related potential (ERP) components elicited during a selective proces...

Phenylketonuria (PKU) is one of the most prevalent types of hereditary metabolic disorders which is caused due to an absence or reduction of the activity of the Phenylalanine hydroxylase enzyme in the liver which in turn, inhibits the transformation of phenylalanine (Phe) to tyrosine. In clinical terms, this disorder is displayed with severe, permanent and irreversible mental retardation. This ...

Understanding the structures of active and inactive agonist- and antagonist-bound receptor complexes is of great interest. In this work, we focus on position 30 of cholecystokinin (CCK) and its spatial approximation with the type A CCK receptor. For this, we developed two photoaffinity labeling probes, replacing the naturally occurring tryptophan with p-benzoyl-l-phenylalanine (Bpa) or p-nitro-...

Human blood monocytes comprise two subpopulations: one migrates to the chemoattractant. N-formylmethionylleucyl-phenylalanine (fMet-Leu-Phe). and has saturable binding sites for this peptide; the other does not migrate and exhibits little peptide binding. To determine if expression of binding sites was a function of monocyte maturation. we depleted human subjects of blood monocytes by leukapher...