The composition of biologically active substances in the aqueous total fraction 95% EtOH extract aerial part Alfredia cernua (L.) Cass. possessing antiamnesic properties was studied using chromatographic and mass-spectrometric methods. amount N-containing compounds found to be 10.63 ± 1.65%. Fifteen amino acids (1.99 0.11%), seven which (0.76 0.012%) were essential included lysine, threonine, v...

The delivery of large neutral amino acids (LNAAs) to brain across the blood-brain barrier (BBB) is mediated by the L-type neutral amino acid transporter present in the membranes of the brain capillary endothelial cell. In experimental animals, the L-system transporter is saturated under normal conditions, and therefore an elevation in the plasma concentration of one LNAA will reduce brain uptak...

OBJECTIVE Branched-chain and aromatic amino acids are associated with the risk for future type 2 diabetes; however, the underlying mechanisms remain elusive. We tested whether amino acids predict insulin resistance index in healthy young adults. RESEARCH DESIGN AND METHODS Circulating isoleucine, leucine, valine, phenylalanine, tyrosine, and six additional amino acids were quantified in 1,680...

We determined the effect of insulin and/or recombinant human (rh)IGF-I infusion on ovine fetal phenylalanine kinetics, protein synthesis, and phenylalanine accretion. The chronically catheterized fetal lamb model was used at 130 days gestation. All studies were performed while fetal glucose and amino acid concentrations were held constant. Experimental infusates were 1). saline, 2). rhIGF-I plu...

Myocardial protein turnover in vivo was examined in anesthetized dogs following a 16- or 36-hour fast and again during a hyperinsulinemic (2 mU/kg per minute) euglycemic clamp with or without amino acid replacement or during saline infusion. We measured myocardial phenylalanine balance and rates of protein synthesis and degradation, using the extraction of intravenously infused L-[ring-2,6-3H]p...

In preceding papers (1, 2), it was shown that premature infants fed vitamin C-free cow's milk mixtures, high in protein (5 grams or more per kgm. per day), exhibit a spontaneous defect in their metabolism of tyrosine and phenylalanine, manifested by the urinary excretion of 1-p-hydroxyphenyllactic and p-hydroxyphenylpyruvic acids. The defect was accentuated by feeding these subjects either amin...

This chapter describes the aromatic L‐amino acids tryptophan and tyrosine and the effects on tyrosine metabolism of phenylalanine. Tryptophan and phenylalanine are essential amino acids and must ultimately be derived from dietary proteins; tyrosine is obtained both from dietary proteins and from the hydroxylation of phenylalanine by phenylalanine hydroxylase (PAH). The proportions of dietary tr...

The aim of this work is to research the interactions water-soluble nitrogen-containing copolymers with essential amino acids in aqueous media. For this, poly(N-vinylformamide-co-N-vinylimidazole) and poly(N-vinylcaprolactam-co-N-vinylimidazole) random were synthesized by free radical polymerization. products obtained are characterized GPC, DLS, FTIR. have a narrow molecular weight distribution ...

Sea weeds belonging to the Rhodophyceae (red algae) are an important source of bio active substances medicinal value. Many these used in drug development treat diseases caused by bacterial and fungal infections, inflammation, pain, arthritis, as well cancerous diseases. The paper chromatographic studies reveals that Grateloupia filicina contained photosynthetic pigment carotene Gracelaria corti...