Although the CD5 (T1) antigen was initially described as a pan-T cell membrane glycoprotein, we report that 14 of 40 normal individuals were found to have 5% or greater of their blood mononuclear cells characterized as CD3 (T3)+ but CDSby dual immunofluorescence flow cytometry. These cells expressed normal quantities of surface CD3 and CD2 but low levels of CD7, were CD8' and CD4-, and CD16-. I...

The interrelationships among phenotypic traits of plants has been of interest to plant evolutionary biologists for almost a century. Broadly defined, phenotypic integration refers to the correlations among traits within functional units (such as a flower). In this review, the classic research of Berg (1960) on the relationships among traits within floral modules, the dissociation of the floral ...

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Microarray technology has become a very popular approach in cases where multiple experiments need to be conducted repeatedly or done with a variety of samples. In our lab, we are applying our high density spots microarray approach to microscopy visualization of the effects of transiently introduced siRNA or cDNA on cellular morphology or phenotype. In this publication, we are discussing the pos...

A cornerstone of evolutionary theory is that the phenotypic variance of a population may be partitioned into genetic and environmental (nonheritable) components. The traditional motivation for this distinction is that the rate of evolution under natural selection depends on the (relative) magnitudes of certain genetic components of variance. The components of variation are also interesting from...

Objective: Castor (Ricinuscommunis L.) is an industrial oilseed that belongs to the family Euphorbiaceae. Castor is believed to be originated in East Africa probably Ethiopia. Although Ethiopia is known as a primary diversity for castor the knowledge on nature and extent of variation of the indigenous germplasm is limited. The present test was conducted to study the nature and extent o...

Objective: Castor (Ricinuscommunis L.) is an industrial oilseed that belongs to the family Euphorbiaceae. Castor is believed to be originated in East Africa probably Ethiopia. Although Ethiopia is known as a primary diversity for castor the knowledge on nature and extent of variation of the indigenous germplasm is limited. The present test was conducted to study the nature and extent o...

High-frequency reversible changes in colony morphology were observed in three strains of Cryptococcus neoformans. For one strain (SB4, serotype A), this process produced three colony types: smooth (S), wrinkled (W), and serrated (C). The frequency of switching between colony types varied for the individual colony transitions and was as high as 10(-3). Mice infected with colony type W died faste...

High-throughput phenotyping projects in model organisms have the potential to improve our understanding of gene functions and their role in living organisms. We have developed a computational, knowledge-based approach to automatically infer gene functions from phenotypic manifestations and applied this approach to yeast (Saccharomyces cerevisiae), nematode worm (Caenorhabditis elegans), zebrafi...