BACKGROUND The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza Bge., DS). This medicine is extensively used to treat cardiovascular disease. METHODS...

The glucuronidation of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (compound 1), a potent inhibitor of DNA topoisomerase I, and its related indolocarbazole compounds was studied using human liver microsomes. Compound 1 and its structurally related compounds with the NHCHO moiety at the N-6 position were glucuronida...

Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this c...

Catalase isozymes of maize (Zea mays, L. hybrid Norma) were shown to differ in their sensitivity to phenolic compounds. Salicylic acid, benzoic acid, acetylsalicylic acid and o-coumaric acid caused significantly greater inhibition of CAT1 activity than of CAT2. The nature of inhibition was non-competitive for CAT1, while CAT2 was inhibited competitively. P-hydroxybenzoic acid (pHBA) was the onl...

The synthesis and characterization of di-n-butyltin and dimethyltin salicyloxamate, respectively compounds 1 and 2, are reported. Compound 1 is more active than cisplatin, 5-fluorouracil and etoposide against seven tumoural cell lines of human origin, but less active than methotrexate and doxorubucin. Diorganotin derivatives of salicylic acid and its substituted analogs exhibit antitumour activ...

The primary and secondary 18O isotope effects for the alkaline (KOH) and enzymatic (phosphotriesterase) hydrolysis of two phosphotriesters, O,O-diethyl p-nitrophenyl phosphate (I) and O,O-diethyl O-(4-carbamoylphenyl) phosphate (II), are consistent with an associative mechanism with significant changes in bond order to both the phosphoryl and phenolic leaving group oxygens in the transition sta...

background: olive oil wastewater  contains chemical contents and organic materials that are resistant to biodegradation.  the existence of phenolic inhibitor compounds, toxicity to microorganisms in wastewater treatment units, unpleasant odor, high biochemical oxygen demand (bod) and chemical oxygen demand (cod), high suspended solids, and compounds resistant to biodegradation in such wastewate...

Background & Aim: Nowdays consumers prefer to eat healthier foods, therefore producers and researchers are involved to improve the variety, quality, taste of food products. Lemon balm is a perennial, aromatic, herb that contains many phenolic compounds. In this research the effect of additing lemon balm powder (by reducing of wheat flour in formulation, instead) on qualities of sponge cakes wer...

From methanolic extract of aerial parts of Peucedanum ruthenicum M. Bieb (Apiaceae) collected from Mazandaran province of Iran, four flavonoids namely Isorhamnetin 3-0-rutinoside 1, rutin 2, quercetin 3, morin 4 and two phenolic acids namely caffeic acid 5 and p-coumaric acid 6 have been isolated by Paper Chromatography (PC) and crystallization. Their structures were elucidated by MS, 1H, 13C N...

From methanolic extract of aerial parts of Peucedanum ruthenicum M. Bieb (Apiaceae) collected from Mazandaran province of Iran, four flavonoids namely Isorhamnetin 3-0-rutinoside 1, rutin 2, quercetin 3, morin 4 and two phenolic acids namely caffeic acid 5 and p-coumaric acid 6 have been isolated by Paper Chromatography (PC) and crystallization. Their structures were elucidated by MS, 1H, 13C N...