نتایج جستجو برای: phenol ortho alkylation

تعداد نتایج: 27115  

2015
Takumi Satoh Romain Stalder Scott R. McKercher Robert E. Williamson Gregory P. Roth Stuart A. Lipton

Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endoplasmic reticulum stress. Electrophilic compounds have been shown to be activators of these transcription-mediated responses through S-alkylation o...

Journal: :Organic & biomolecular chemistry 2014
Thomas Biet Narcis Avarvari

The donor ortho-dimethyl-TTF-(N-n-Bu-1,2,3-triazole) 1,5-isomer has been synthesized by click chemistry following a ruthenium-catalyzed azide-alkyne cycloaddition procedure. The single crystal X-ray analysis showed a planar conformation between the TTF and triazole units and a set of intermolecular interactions at the supramolecular level in the solid state. The same procedure allowed the prepa...

2014
Narcis Avarvari

PAPER Thomas Biet and Narcis Avarvari Tetrathiafulvalene mono-and bis-1,2,3-triazole precursors by click chemistry: structural diversity and reactivity The donor ortho-dimethyl-TTF-(N-n-Bu-1,2,3-triazole) 1,5-isomer has been synthesized by click chemistry following a ruthenium-catalyzed azide–alkyne cycloaddition procedure. The single crystal X-ray analysis showed a planar conformation between ...

2014
Witold Żukowski Gabriela Berkowicz Jerzy Baron Stanisław Kandefer Dariusz Jamanek Stefan Szarlik Zbigniew Wielgosz Maria Zielecka

BACKGROUND 2,6-dimethylphenol (2,6-DMP) is a product of phenol methylation, especially important for the plastics industry. The process of phenol methylation in the gas phase is strongly exothermic. In order to ensure good temperature equalization in the catalyst bed, the process was carried out using a catalyst in the form of a fluidized bed - in particular, the commercial iron-chromium cataly...

Journal: :Organic & biomolecular chemistry 2015
Denise Pauli Stefan Bienz

A recently introduced new SPS resin, possessing a 2-(ortho-nitrophenyl)ethanal linker, was used for the regioselective on-resin synthesis of N-mono-hydroxylated and N-mono-methylated polyamine spider toxins of Agelenopsis aperta and Larinioides folium. The polyamine backbones of the target compounds were efficiently constructed from the center by reductive amination of the aldehyde linker, foll...

Journal: :Molecules 2009
Pi Cheng Ji-Jun Chen Ning Huang Rui-Rui Wang Yong-Tang Zheng Yi-Zeng Liang

A series of (E)-N-phenylstyryl-N-alkylacetamides, 5, were synthesized by direct reduction-acetylation of beta-arylnitroolefins, followed by N-alkylation. The title compounds were characterized by (1)H-NMR, EIMS and IR analysis. All the synthesized compounds were assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors. A SAR study revealed that when group R(1) in 5 was ortho-substituted...

Journal: :Macromolecular Rapid Communications 2021

A new methodology for the pH-triggered degradation of polymers or release drugs under visible light irradiation based on cyclization ortho-hydroxy-cinnamates (oHC) to coumarins is described. The key oHC structural motif can be readily incorporated into rational design novel photocleavable via click chemistry. This main-chain moiety undergoes a fast photocleavage when irradiated with 455 nm prov...

2015
Giacomo E M Crisenza Olga O Sokolova John F Bower

An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine d(F) ppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl- or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standi...

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