نتایج جستجو برای: pharmacokinetic
تعداد نتایج: 25201 فیلتر نتایج به سال:
The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...
BACKGROUND Lopinavir/ritonavir (LPV/r) is an effective and commonly used protease inhibitor in HIV-infected adolescents. Previous data showed high plasma concentrations of LPV in Thai patients. This study determined the pharmacokinetic (PK) parameters of a low-dose LPV/r tablet (70% of standard dose) in HIV-infected Thai adolescents. METHODS A total of 24 adolescents on LPV/r-containing HAART...
Pharmacokinetic studies are an integrated part of the development program of a new drug. They are intended to define the time course of drug and major metabolite concentrations in plasma and other biological fluids in order to obtain information on absorption, distribution, metabolism, and elimination. In preclinical studies, pharmacokinetics (PK) is often used to interpret toxicological result...
In this paper, we develop a method of forming pharmacokinetic-rate images of indocyanine green (ICG) and apply our method to in vivo data obtained from three patients with breast tumors. To form pharmacokinetic-rate images, we first obtain a sequence of ICG concentration images using the differential diffuse optical tomography technique. We next employ a two-compartment model composed of plasma...
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