Different clinical response of different patients to the same medicine has been recognised and documented since the 1950's. Variability in response of individuals to standard doses of drug therapy is important in clinical practice and can lead to therapeutic failures or adverse drug reactions. Pharmacogenetics seeks to identify individual genetic differences (polymorphisms) in drug absorption, ...

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The Human Genome Project has resulted in a new era in the field of pharmacogenetics in which researchers are rapidly discovering new genetic variation, which may help to explain interindividual variability in drug efficacy and toxicity. Pharmacogenetics is the study of the role of genetic inheritance in individual variation in drug response and toxicity. With the convergence of advances in phar...

Inspite of great successes in treatment and high incidence surveillance pediatric acute lymphoblastic leukemia (ALL), patients are addicted to many drugs adverse events, which sometimes indicate decrease the dose or even cytotoxic drug interruption with following risk secondary disease relapse. Besides, researches found significant inter-individual variability toxicity outcome. This fact specif...