The purpose of this work was to develop a rapid, sensitive and validated HPLC method for the separation and analysis of a Bromazepam, Medazepam and Midazolam mixture. The three benzodiazepine compounds were separated on a reversed-phase C18 column at 50 °C using a mobile phase containing 25% acetonitrile, 45% methanol and 30% ammonium acetate (0.05 M). The pH was adjusted to pH=9 by the additio...

calibration transfer method is evaluated by transferring multivariate models between two equivalent near-infrared (NIR) analyzers for the prediction of A an Active Pharmaceutical Ingredient (API) in tablets. The method includes selecting a few representative samples, building a transformation relation, and standardizing spectra. Backward and forward transfer approaches are compared. A practical...

Sodium benzoate, potassium sorbate, and methyl hydroxybenzoate are commonly used as preservatives in liquid pharmaceutical preparations. The purpose of this study is to determine the amount of the aforementioned preservatives in pharmaceutical products, as some recent studies have reported serious side effects associated with the ingestion of these substances. The content of 37 liquid pharmaceu...

“We try never to forget that medicine is for the people. It is not for the profits. The profits follow.”1 This noble mantra is longforgotten in today’s world of extreme pharmaceutical marketing tactics, which are frequently deceptive and supported by biased information. Pharmaceutical manufacturers often appear to forget their moral purpose and instead engage in the hard sell, stopping at nothi...

BACKGROUND The antimicrobial resistance is a global problem, probably due to the indiscriminate and irrational use of antibiotics, prescriptions for incorrect medicines or incorrect determinations of dose, route and/or duration. Another consideration is the uncertainty of patients receiving antibiotics about whether the quality of a generic medicine is equal to, greater than or less than its eq...

Thirty nine brands of pharmaceutical dosage forms (28 tablets, 4 syrups, 6 suspensions and one chewing gum) that are available in United Arab Emirates pharmaceutical markets were investigated for the presence of three heavy metals; lead, cadmium and nickel. Amongst the samples, 13 products were manufactured locally in United Arab Emirates and 26 products were imported from around the world. The...

Recently, mass spectrometric related techniques have been widely applied for the identification and quantification of neurochemicals and their metabolites in biofluids. This article presents an overview of mass spectrometric techniques applied in the detection of neurological substances and their metabolites from biological samples. In addition, the advances of chromatographic methods (LC, GC a...

BACKGROUND A national multimedia campaign was launched in January 2010, to increase the proportion of young people tested for chlamydia. This study aimed to evaluate the impact of the campaign on the coverage and positivity within the National Chlamydia Screening Programme (NSCP) in England. METHOD An interrupted time series of anonymised NCSP testing reports for England for a 27 month period...

Fluvoxamine (FVX) can be reduced at a mercury-drop electrode, with a maximum peak current intensity being obtained at a potential of -0.7 V vs. Ag/AgCl, in an aqueous electrolyte solution of pH 2. The compound was determined in a pharmaceutical product and in spiked human serum by square-wave adsorptive-stripping voltammetry (SWAdSV) after accumulation at the electrode surface, under batch cond...

Diclofenac is a Non-steroidal anti-inflammatory drugs (NSAIDs) are the group most widely used in human and veterinary medicine, since it is available without prescription for treatment of fever and minor pain. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control and pharmacodynamics and pharmacokinetic studies. An extensive survey ...