the present study reports formulation of a traditionally used poly herbal product for wound healing and its chromatographic analysis by hptlc. herbal therapy was the common treatment prescribed by iranian physicians for wound healing. “zemad”, the most ancient pharmaceutical dosage form used in the iranian traditional medicine (itm) for skin diseases. in this study, a poly herbal paste (php) wi...

Novel simple kinetic spectrophotometric method for the determination of tiopronin [N-(2mercaptopropionyl)-glycine, MPG] in pharmaceutical formulation has been developed and validated. The proposed method is based on the coupled redox-complexation reaction whose first step is reduction of Fe by MPG, while second one includes the complexation of Fe, resulted from preceding redox reaction, with 2,...

Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

UV, first, second and third derivative spectrophotometric methods have been developed for the determination of ezetimibe in pharmaceutical formulation. The solutions of standard and sample were prepared in methanol. For the first method, UV spectrophotometry, the quantitative determination of the drug was carried at 233 nm and the linearity range was found to be 6-16 mug/ml. For the first, seco...

scarcely pharmaceutical applications. Recent investigations state its utility in dissolution enhancement of poorly soluble drugs, amorphous state stabilization and extended drug release. To broaden the applications of MC as a pharmaceutical excipient, need has been felt to test its antigenicity owing to its proteinic nature. In silico antigenicity screening has been carried out to enable its us...

To assess the comparative bioavailability of two cyclosporine capsule products with different pharmaceutical formulation an open randomized two-period cross over study was conducted in 24 healthy volunteers. Our results, obtained from cyclosporine HPLC determination onto the whole blood samples collected, show that the test cyclosporine non-SMEDDS formulation was not bioequivalent cyclosporine ...

This paper describes the formulation and quality control of an aqueous sterilized formulation of the experimental cytostatic drug cyclopentenyl cytosine (CPEC) to be used in Phase I/II clinical trials. The raw drug substance was extensively tested. A High Pressure Liquid Chromotography (HPLC) method was validated for the quality control of the formulated product. The aqueous formulation was fou...

Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical companies in the market. In ophthalmic formulation to the eye like solutions, suspensions, and ointments are available in the market shows drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision. The major problem associated with the conventi...

Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 18...

Designing a global pricing strategy for a new pharmaceutical product has become increasingly difficult as geographic reference pricing and parallel trade have introduced global price interdependencies between different nations. What may have been an optimal pricing strategy in a single country may no longer be optimal when considering the international ramifications of this price. The prices se...