Background and Objective: Phage therapy could be used as an alternative method to antibiotic treatments. The purpose of this study was to evaluate the antibacterial activities of isolated lytic bacteriophage against ciprofloxacin-resistant strain of Salmonella infanits in vitro conditions. Materials and Methods: The standard strain of Salmonella infantis  and its specific bacteriophage was iso...

The ability to induce anti-HIV-1 antibodies that can neutralize a broad spectrum of viral isolates from different subtypes seems to be a key requirement for development of an effective HIV-1 vaccine. The epitopes recognized by the most potent broadly neutralizing antibodies that have been characterized are largely discontinuous. Mimetics of such conformational epitopes could be potentially used...

D rug abuse is a major public health problem, and, although there are many treatments of proven efficacy, the majority of patients are not permanently cured, with relapse rates on the order of 70% or more in the first years for the treatment of almost all drugs of addiction. Therefore, there is a great need for new and improved therapies. Carrera et al. (1) have pioneered the use of one of the ...

Phage contamination has become a major concern for industrial bacteria, such as Escherichia coli BL21(DE3), used in fermentation processes. Herein, we report CRISPR/Cas9 defense system-based strategy to precisely prey and degrade phage DNA decontaminate target phages. First, isolated novel from substrates with BL21(DE3) the host, named TR1. It showed typical podovirus morphology head diameter o...

Limosilactobacillus fermentum is a bacterium widely used in food production, medicine, and industrial fermentation. However, fermentation could fail due to phage contamination. L. bacteriophage LFP02 can be induced from IMAU 32579 using mitomycin C. To better understand the characteristics of this phage, its physiological genomic were evaluated. The results showed that optimal multiplicity infe...

nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. in view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

Random peptide libraries (RPL) displayed on the surface of filamentous bacteriophages have been extensively used as a tool to map epitopes or to identify antigenic mimics (mimotpoes) of disease-specific monoclonal antibodies or polyclonal sera. These RPL are engineered by the insertion of degenerate oligonucleotides, encoding a specific number of random amino acids, in frame with a bacteriophag...

Australian bat lyssavirus (ABLV) is a rhabdovirus that circulates in four species of pteropid bats (ABLVp) and the yellow-bellied sheath-tailed (ABLVs) mainland Australia. In three confirmed human cases ABLV, rabies illness preceded fatality. As with virus (RABV), post-exposure prophylaxis (PEP) for potential ABLV infections consists wound cleansing, administration vaccine injection immunoglobu...